Effectiveness of Oil-Based Denture Dentifrices-Organoleptic Characteristics, Physicochemical Properties and Antimicrobial Action

Author(s)

dos Santos, Andrezza C. M. ^[1] ; Oliveira, Viviane C. ^{[2, 1]} ; Macedo, Ana P. ^[1] ; Bastos, Jairo K. ^[3] ; Ogasawara, Mario S. ^[3] ; Watanabe, Evandro ^{[4, 2]} ; Chaguri, Isabela M. ^[1] ; Silva-Lovato, Claudia H. ^[1] ; Paranhos, Helena F. O. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Dent Mat & Prosthodont, Cafe Ave S-N, BR-14040904 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Sch Nursing Ribeirao Preto, Human Exposome & Infect Dis Network HEID, Bandeirantes Ave 3900, BR-14040904 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Pharmaceut Sci, BR-14040904 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Restorat Dent, BR-14040904 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: ANTIBIOTICS-BASEL; v. 10, n. 7 JUL 2021.
• Web of Science Citations: 0

Abstract

Denture dentifrices must be effective and not deleterious to prosthetic devices. This study formulated and evaluated dentifrices based on oils of Copaifera officinalis, Eucalyptus citriodora, Melaleuca alternifolia, Pinus strobus, and Ricinus communis. Organoleptic characteristics (appearance, color, odor, taste), physicochemical properties (pH, density, consistency, rheological, abrasiveness, weight loss, and surface roughness) and antimicrobial (Hole-Plate Diffusion-HPD)/anti-biofilm (Colony Forming Units-CFU) action against Staphylococcus aureus, Streptococcus mutans, and Candida albicans were evaluated. Formulations were compared with water (negative control) and a commercial dentifrice (positive control). The data were analyzed by Kruskal-Wallis and Dunn tests (alpha = 0.05). The organoleptic and physicochemical properties were adequate. All dentifrices promoted weight losses, with high values for C. officinalis and R. communis, and an increase in surface roughness, without differing from each other. For antimicrobial action, C. officinalis and E. citriodora dentifrices were similar to positive control showing effectiveness against S. mutans and C. albicans and no dentifrice was effective against S. aureus; regarding the anti-biofilm action, the dentifrices were not effective, showing higher CFU counts than positive control for all microorganisms. The dentifrices presented satisfactory properties; and, although they showed antimicrobial action when evaluated by HPD, they showed no effective anti-biofilm action on multispecies biofilm. (AU)

• FAPESP's process: 19/02404-8 - Evaluation of experimental dentifrices based on essential oils for total prosthesis hygiene - in vitro and in vivo studies
• Grantee: Helena de Freitas Oliveira Paranhos
• Support Opportunities: Regular Research Grants