| Full text | |
| Author(s): |
Altaf-Ul-Amin, Md.
[1]
;
Hirose, Kazuhisa
[1]
;
Nani, Joao V.
[2, 3]
;
Porta, Lucas C.
[2]
;
Tasic, Ljubica
[4]
;
Hossain, Shaikh Farhad
[1]
;
Huang, Ming
[1]
;
Ono, Naoaki
[1]
;
Hayashi, Mirian A. F.
[2, 3]
;
Kanaya, Shigehiko
[1]
Total Authors: 10
|
| Affiliation: | [1] Nara Inst Sci & Technol, Nara 6300192 - Japan
[2] Univ Fed Sao Paulo UNIFESP, Dept Pharmacol, Escola Paulista Med EPM, Sao Paulo, SP - Brazil
[3] Natl Inst Translat Med, INCT TM, CNPq, FAPESP, CAPES, Ribeirao Preto - Brazil
[4] Univ Estadual Campinas UNICAMP, Inst Chem, Dept Organ Chem, Chem Biol Lab, Campinas, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 11, n. 1 JUL 14 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Mental disorders (MDs), including schizophrenia (SCZ) and bipolar disorder (BD), have attracted special attention from scientists due to their high prevalence and significantly debilitating clinical features. The diagnosis of MDs is still essentially based on clinical interviews, and intensive efforts to introduce biochemical based diagnostic methods have faced several difficulties for implementation in clinics, due to the complexity and still limited knowledge in MDs. In this context, aiming for improving the knowledge in etiology and pathophysiology, many authors have reported several alterations in metabolites in MDs and other brain diseases. After potentially fishing all metabolite biomarkers reported up to now for SCZ and BD, we investigated here the proteins related to these metabolites in order to construct a protein-protein interaction (PPI) network associated with these diseases. We determined the statistically significant clusters in this PPI network and, based on these clusters, we identified 28 significant pathways for SCZ and BDs that essentially compose three groups representing three major systems, namely stress response, energy and neuron systems. By characterizing new pathways with potential to innovate the diagnosis and treatment of psychiatric diseases, the present data may also contribute to the proposal of new intervention for the treatment of still unmet aspects in MDs. (AU) | |
| FAPESP's process: | 20/01107-7 - Study to optimize the use of crotamine as a theranostic in the therapy of human diseases: cancer, metabolic syndrome and renal dysfunction |
| Grantee: | Mirian Akemi Furuie Hayashi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/03102-2 - Optimization of the antitumor treatment with crotamine through oral route |
| Grantee: | Lucas de Carvalho Porta |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 19/09207-3 - Study of molecular and cellular mechanisms in mental disorders |
| Grantee: | João Victor Silva Nani |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 19/13112-8 - Study of molecular and cellular mechanisms involved in mental disorders: clinical and animal models analysis |
| Grantee: | Mirian Akemi Furuie Hayashi |
| Support Opportunities: | Research Projects - Thematic Grants |