Composition-Structure-Solubility Relationships in Borosilicate Glasses: Toward a Rational Design of Bioactive Glasses with Controlled Dissolution Behavior

Author(s)

Stone-Weiss, Nicholas ^[1] ; Bradtmueller, Henrik ^{[2, 3]} ; Eckert, Hellmut ^{[2, 4]} ; Goel, Ashutosh ^[1]

Affiliation

^[1] Rutgers State Univ, Dept Mat Sci & Engn, Piscataway, NJ 08854 - USA

^[2] WWU Munster, Inst Phys Chem, D-48149 Munster - Germany

^[3] Univ Fed Sao Carlos, Dept Mat Engn, BR-13565905 Sao Carlos, SP - Brazil

^[4] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: ACS APPLIED MATERIALS & INTERFACES; v. 13, n. 27, p. 31495-31513, JUL 14 2021.
• Web of Science Citations: 0

Abstract

Owing to their fast but tunable degradation kinetics (in comparison to silicates) and excellent bioactivity, the past decade has witnessed an upsurge in the research interest of borate/ borosilicate-based bioactive glasses for their potential use in a wide range of soft tissue regeneration applications. Nevertheless, most of these glasses have been developed using trial-and-error approaches wherein SiO2 has been gradually replaced by B2O3. One major reason for using this empirical approach is the complexity of shortto-intermediate range structures of these glasses which greatly complicate the development of a thorough understanding of composition-structure-solubility relationships in these systems. Transitioning beyond the current style of composition design to a style that facilitates the development of bioactive glasses with controlled ion release tailored for specific patients/diseases requires a deeper understanding of the compositional/structural dependence of glass degradation behavior in vitro and in vivo. Accordingly, the present study aims to decipher the structural drivers controlling the dissolution kinetics and ion-release behavior of potentially bioactive glasses designed in the Na2O-B2O3-P2O5-SiO2 system across a broad compositional space in simulated body environments (pH = 7.4). By employing state-of-the-art spectroscopybased characterization techniques, it has been shown that the degradation kinetics of borosilicate glasses depend on their R (Na2O/B2O3) and K (SiO2/B2O3) ratios, while the release of particular network-forming moieties from the glass into solution is strongly influenced by their role in.and effect on.the short-to-intermediate-range molecular structure. The current study aims to promote a rational design of borosilicate-based bioactive glasses, where a delicate balance between maximizing soft tissue regeneration and minimizing calcification and cytotoxicity can be achieved by tuning the release of ionic dissolution products (of controlled identity and abundance) from bioactive glasses into physiological media. (AU)

• FAPESP's process: 13/07793-6 - CEPIV - Center for Teaching, Research and Innovation in Glass
• Grantee: Edgar Dutra Zanotto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 19/26399-3 - Elucidating structural rearrangements during glass relaxation and crystallization
• Grantee: Henrik Bradtmüller
• Support Opportunities: Scholarships in Brazil - Post-Doctoral