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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exosome-Based Vaccines: History, Current State, and Clinical Trials

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Santos, Patrick [1] ; Almeida, Fausto [1]
Total Authors: 2
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto - Brazil
Total Affiliations: 1
Document type: Review article
Source: FRONTIERS IN IMMUNOLOGY; v. 12, JUL 14 2021.
Web of Science Citations: 4

Extracellular vesicles (EVs) are released by most cell types as part of an intracellular communication system in crucial processes such as inflammation, cell proliferation, and immune response. However, EVs have also been implicated in the pathogenesis of several diseases, such as cancer and numerous infectious diseases. An important feature of EVs is their ability to deliver a wide range of molecules to nearby targets or over long distances, which allows the mediation of different biological functions. This delivery mechanism can be utilized for the development of therapeutic strategies, such as vaccination. Here, we have highlighted several studies from a historical perspective, with respect to current investigations on EV-based vaccines. For example, vaccines based on exosomes derived from dendritic cells proved to be simpler in terms of management and cost-effectiveness than dendritic cell vaccines. Recent evidence suggests that EVs derived from cancer cells can be leveraged for therapeutics to induce strong anti-tumor immune responses. Moreover, EV-based vaccines have shown exciting and promising results against different types of infectious diseases. We have also summarized the results obtained from completed clinical trials conducted on the usage of exosome-based vaccines in the treatment of cancer, and more recently, coronavirus disease. (AU)

FAPESP's process: 19/25826-5 - Role of human Breast Cancer-derived extracellular vesicles in immune regulation and acquired drug resistance
Grantee:Patrick Wellington da Silva dos Santos
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/03322-7 - Role of galectin-3 in the Cryptococcus neoformans infection
Grantee:Fausto Bruno dos Reis Almeida
Support type: Research Grants - Young Investigators Grants