| Full text | |
| Author(s): Show less - |
Hara, Toshiro
[1, 2, 3, 4, 5, 6]
;
Chanoch-Myers, Rony
[7]
;
Mathewson, Nathan D.
[4, 8, 9]
;
Myskiw, Chad
[1]
;
Atta, Lyla
[10]
;
Bussema, Lillian
[2, 3, 4, 5, 6]
;
Eichhorn, Stephen W.
[11, 12]
;
Greenwald, Alissa C.
[7]
;
Kinker, Gabriela S.
[13, 7]
;
Rodman, Christopher
[2, 3, 5]
;
Castro, L. Nicolas Gonzalez
[2, 3, 14, 4, 5, 6, 15, 16]
;
Wakimoto, Hiroaki
[2, 17]
;
Rozenblatt-Rosen, Orit
[4, 6, 18]
;
Zhuang, Xiaowei
[11, 12]
;
Fan, Jean
[10]
;
Hunter, Tony
[1]
;
Verma, Inder M.
[1]
;
Wucherpfennig, Kai W.
[4, 8, 9]
;
Regev, Aviv
[4, 6, 18, 19]
;
Suva, Mario L.
[2, 3, 4, 5, 6]
;
Tirosh, Itay
[7]
Total Authors: 21
|
| Affiliation: Show less - | [1] Salk Inst Biol Studies, Lab Genet, La Jolla, CA 92037 - USA
[2] Harvard Med Sch, Boston, MA 02114 - USA
[3] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 - USA
[4] Broad Inst Harvard & MIT, Cambridge, MA 02142 - USA
[5] Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02114 - USA
[6] Broad Inst Harvard & MIT, Klarman Cell Observ, Cambridge, MA 02142 - USA
[7] Weizmann Inst Sci, Dept Mol Cell Biol, IL-761001 Rehovot - Israel
[8] Harvard Med Sch, Boston, MA 02215 - USA
[9] Dana Farber Canc Inst, Dept Canc Immunol & Virol, Dept Microbiol & Immunobiol, Dept Neurol, Boston, MA 02215 - USA
[10] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 - USA
[11] Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 - USA
[12] Harvard Univ, Dept Chem & Chem Biol, Dept Phys, Cambridge, MA 02138 - USA
[13] Univ Sao Paulo, Inst Biosci, Dept Physiol, Sao Paulo - Brazil
[14] Harvard Med Sch, Boston, MA 02115 - USA
[15] Brigham & Womens Dana Farber Canc Ctr, Dept Neurol, Boston, MA 02115 - USA
[16] Brigham & Womens Dana Farber Canc Ctr, Ctr Neurooncol, Boston, MA 02115 - USA
[17] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 - USA
[18] Genentech Inc, 1 DNA Way, San Francisco, CA - USA
[19] MIT, Koch Inst Integrat Canc Res, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 - USA
Total Affiliations: 19
|
| Document type: | Journal article |
| Source: | CANCER CELL; v. 39, n. 6, p. 779+, JUN 14 2021. |
| Web of Science Citations: | 7 |
| Abstract | |
The mesenchymal subtype of glioblastoma is thought to be determined by both cancer cell-intrinsic alterations and extrinsic cellular interactions, but remains poorly understood. Here, we dissect glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments. We demonstrate that macrophages induce a transition of glioblastoma cells into mesenchymal-like (MES-like) states. This effect is mediated, both in vitro and in vivo, by macrophage-derived oncostatin M(OSM) that interacts with its receptors (OSMR or LIFR) in complex with GP130 on glioblastoma cells and activates STAT3. We show that MES-like glioblastoma states are also associated with increased expression of a mesenchymal program in macrophages and with increased cytotoxicity of T cells, highlighting extensive alterations of the immune microenvironment with potential therapeutic implications. (AU) | |
| FAPESP's process: | 14/27287-0 - Characterization of the melatonergic system of human gliomas and its implication on tumor aggressiveness and invasiveness |
| Grantee: | Gabriela Sarti Kinker |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 17/24287-8 - The role of tumor microenvironment elements in malignant cell plasticity and heterogeneity |
| Grantee: | Gabriela Sarti Kinker |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |