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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multifaceted effect of caffeic acid against Streptococcus mutans infection: microbicidal and immunomodulatory agent in macrophages

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Author(s):
Sorgi, Carlos Arterio [1] ; de Campos Chaves Lamarque, Giuliana [2] ; Verri, Maraisa P. [3] ; Nelson-Filho, Paulo [2] ; Faccioli, Lucia Helena [3] ; Paula-Silva, Francisco Wanderley Garcia [3, 2]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Chem, Sch Philosophy Sci & Letters Ribeirao Preto, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Pediat Clin, Sch Dent Ribeirao Preto, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Archives of Microbiology; v. 203, n. 6, p. 2979-2987, AUG 2021.
Web of Science Citations: 0
Abstract

The aim of the present study was to investigate the effects of caffeic acid in the interface between the antimicrobial and anti-inflammatory function in macrophage response against S. mutans. S. mutans (10(8) cfu/mL) were incubated with caffeic acid to determinate the half-maximal inhibitory concentration (IC50) and macrophage cells were incubated with caffeic acid to determinate cell viability and toxicity. Anti-inflammatory effects were measured by nitrite accumulation, TNF-alpha and PGE(2) production, and NF-kB phosphorylation, and S. mutans survival following internalization by macrophages was investigated. We found that caffeic acid presented antimicrobial activity against S. mutans (IC50 = 2.938 +/- 0.1225 mM) without exerting cytotoxicity. Caffeic acid inhibited nitrite, TNF-alpha and PGE(2) production by the NF-kB dependent pathway, indicating an immunomodulatory property. Caffeic acid also contributed to macrophage bacteria clearance activity. In summary, caffeic acid presented antimicrobial activity against S. mutans and anti-inflammatory effects in macrophages. (AU)

FAPESP's process: 19/00204-1 - Role of tumor necrosis factor-alfa in pulpal and periapical inflammation and repair
Grantee:Francisco Wanderley Garcia de Paula e Silva
Support Opportunities: Regular Research Grants