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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nanosystem functionalization strategies for prostate cancer treatment: a review

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de Araujo, Jennifer Thayanne Cavalcante [1] ; Duarte, Jonatas Lobato [1] ; Di Filippo, Leonardo Delello [1] ; Araujo, Victor Hugo Sousa [1] ; Carvalho, Gabriela Correa [1] ; Chorilli, Marlus [1]
Total Authors: 6
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, BR-14800903 Araraquara, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: Journal of Drug Targeting; v. 29, n. 8, p. 808-821, SEP 14 2021.
Web of Science Citations: 2

Prostate cancer (PC) has a high morbidity and mortality rate worldwide, and the current clinical guidelines can vary depending on the stage of the disease. Drug delivery nanosystems (DDNs) can improve biopharmaceutical properties of encapsulated anti-cancer drugs by modulating their release kinetics, improving physicochemical stability and reducing toxicity. DDN can also enhance the ability of specific targeting through surface modification by coupling ligands (antibodies, nucleic acids, peptides, aptamer, proteins), thus favouring the cell internalisation process by endocytosis. The purposes of this review are to describe the limitations in the treatment of PC, explore different functionalization such as polymeric, lipid and inorganic nanosystems aimed at the treatment of PC, and demonstrate the improvement of this modification for an active target, as alternative and promising candidates for new therapies. (AU)

FAPESP's process: 18/18488-3 - Potential evaluation of nanostructured lipid carriers functionalized with bevacizumab for delivery of docetaxel in the treatment of glioblastoma
Grantee:Leonardo Delello Di Filippo
Support Opportunities: Scholarships in Brazil - Master