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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of Brazilian green propolis extract on planktonic cells and biofilms of multidrug-resistant strains ofKlebsiella pneumoniaeandPseudomonas aeruginosa

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Author(s):
do Rosario Estevam dos Santos, Pamela Beatriz [1, 2] ; Avila, Damara da Silva [1] ; Ramos, Lucas de Paula [1] ; Yu, Amanda Romagnoli [1] ; da Rocha Santos, Carlos Eduardo [1, 3] ; Berretta, Andresa Aparecida [4] ; Afonso Camargo, Samira Esteves [5] ; de Oliveira, Jonatas Rafael [6] ; de Oliveira, Luciane Dias [1]
Total Authors: 9
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP - Brazil
[2] Univ Paulista UNIP, Hlth Sci Inst, Sao Jose Dos Campos, SP - Brazil
[3] Policlin Inst Teaching & Res, Sao Jose Dos Campos, SP - Brazil
[4] Apis Flora Ind Coml Ltda, Res & Dev Lab, Ribeirao Preto, SP - Brazil
[5] Univ Florida, Coll Dent, Dept Restorat Dent Sci, Gainesville, FL - USA
[6] Anhembi Morumbi Univ, Sch Med, Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: BIOFOULING; v. 36, n. 7, p. 834-845, AUG 8 2020.
Web of Science Citations: 0
Abstract

Propolis could represent an alternative therapeutic agent for targeting multidrug-resistant bacteria due to its antimicrobial potential. The effect of Brazilian green propolis (BGP) aqueous extract (AqExt) was evaluated on eight multidrug-resistant clinical strains ofKlebsiella pneumoniaeandPseudomonas aeruginosa, as well as on one reference strain for each bacterial species. The minimum bactericidal concentration (MBC) was determined and optimal concentrations were further evaluated in comparison with 0.12% chlorhexidine. The natural extract was chemically characterized by HPLC-DAD analysis. The MBC values ranged between 3.12 and 27.5 mg ml(-1). Analysis of bacterial metabolic activity after treatment for 5 min with BGP-AqExt revealed a strong antimicrobial potential, similar to chlorhexidine. The extract comprised several active compounds including quercetin, gallic acid, caffeic andp-coumaric acid, drupani, galangin, and artepillin C. Altogether, the findings suggest that BGP-AqExt is fast and effective against multidrug-resistant strains ofK. pneumoniaeandP. aeruginosain planktonic cultures and biofilms. (AU)

FAPESP's process: 15/08776-3 - ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITY, CYTOTOXICITY AND GENOTOXICITY OF DIFFERENT NATURAL EXTRACTS
Grantee:Luciane Dias de Oliveira
Support Opportunities: Regular Research Grants