Effect of supplemental acid-etching on the early stages of osseointegration: A preclinical model

Author(s)

Jalkh, Ernesto B. Benalcazar ^{[1, 2]} ; Parra, Marcelo ^{[3, 4]} ; Torroni, Andrea ^[5] ; Nayak, Vasudev Vivekanand ^{[6, 2]} ; Tovar, Nick ^{[7, 8, 2]} ; Castellano, Arthur ^{[9, 10]} ; Badalov, Rafael M. ^[2] ; Bonfante, Estevam A. ^[1] ; Coelho, Paulo G. ^{[5, 6, 2]} ; Witek, Lukasz ^{[11, 2]}

Affiliation:Show less -

^[1] Univ Sao Paulo, Dept Prosthodont & Periodontol, Bauru Sch Dent, Bauru, SP - Brazil

^[2] NYU, Coll Dent, Dept Biomat, 433 1st Ave, Room 842, New York, NY 10010 - USA

^[3] Univ La Frontera, Fac Dent, Temuco - Chile

^[4] Univ La Frontera, PhD Program Morphol Sci, Ctr Excellence Morphol & Surg Studies, Fac Med, Temuco - Chile

^[5] NYU, Sch Med, Hansjorg Wyss Dept Plast Surg, New York, NY - USA

^[6] NYU, Dept Mech & Aerosp Engn, Tandon Sch Engn, Brooklyn, NY - USA

^[7] Bellevue Hosp Ctr, New York, NY 10016 - USA

^[8] NYU, Dept Oral & Maxillofacial Surg, Langone Med Ctr, New York, NY - USA

^[9] Univ Fed Parana, Curitiba, Parana - Brazil

^[10] Mackenzie Evangel Sch Med Parana, Curitiba, Parana - Brazil

^[11] NYU, Dept Biomed Engn, Tandon Sch Engn, Brooklyn, NY - USA

• Document type: Journal article
• Source: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS; v. 122, OCT 2021.
• Web of Science Citations: 0

Abstract

Purpose: To evaluate the effect of two surface modifications on early osseointegration parameters of conical implants in a translational pre-clinical model. Materials and methods: Conical implants with progressive trapezoidal threads and healing chambers were evaluated consisting of two different surface conditions: 1) Implacil surface (IMP Sur), and 2) Implacil surface + Supplemental Acid-etching (IMP Sur + AE). Surface characterization comprised of the evaluation of roughness parameters (Sa, Sq and Sdr), surface energy and contact angle. Subsequently, implants were installed in the ilium crest of nine female sheep (weighing -65 kg). Torque out, histological and histomorphometric analyses were conducted after 3 and 6 weeks in-vivo. The percentage of bone to implant contact (%BIC) and bone area fraction occupancy within implant threads (%BAFO) were quantified, and the results were analyzed using a general linear mixed model analysis as function of surface treatment and time in-vivo. Results: Supplemental acid etching significantly increased Sa and Sq roughness parameters without compromising the surface energy or contact angle, and no significant differences with respect to Sdr. Torque-out testing yielded significantly higher values for IMP Sur + AE in comparison to the IMP Sur at 3- (62.78 +/- 15 and 33.49 +/- 15 N. cm, respectively) and 6-weeks (60.74 +/- 15 and 39.80 +/- 15 N.cm, respectively). Histological analyses depicted similar osseointegration features for both surfaces, where an intramembranous-type healing pattern was observed. At histomorphometric analyses, IMP Sur + AE implants yielded higher values of BIC in comparison to IMP Sur at 3- (40.48 +/- 38 and 27.98 +/- 38%, respectively) and 6-weeks (45.86 +/- 38 and 34.46 +/- 38%, respectively). Both groups exhibited a significant increase in %BAFO from 3 (-35%) to 6 weeks (-44%), with no significant differences between surface treatments. Conclusion: Supplemental acid-etching and its interplay with implant thread design, positively influenced the BIC and torque-out resistance at early stages of osseointegration. (AU)

• FAPESP's process: 18/03072-6 - Experimental 70% Al2O3-30% ZrO2 composites: structural characterization and survival probability before and after aging
• Grantee: Ernesto Byron Benalcazar Jalkh
• Support Opportunities: Scholarships in Brazil - Doctorate