Comparative Study on the Effects of Paullinia cupana, PC-18 and Magnesium Chloride on Solid Ehrlich Tumor

Author(s)

da Silva, Emerson Barbosa ^[1] ; Chen, Felipe Ko ^[1] ; Perez, Matheus Moreira ^[1] ; Petri, Giuliana ^[1] ; Feder, David ^[1] ; Fonseca, Fernando Luiz Affonso ^{[2, 1]} ; Alves, Beatriz da Costa Aguiar ^[1]

Affiliation

^[1] Ctr Univ Saude ABC, Fac Med ABC, Clin Lab, Ave Principe Gales 821, BR-09060650 Santo Andre, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Pharmaceut Sci, Diadema, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF MEDICINAL FOOD; AUG 2021.
• Web of Science Citations: 0

Abstract

New perspectives arise in the therapeutic practice for cancer, with the objective to not only treat patients, but also improve their quality of life. Guarana, a plant from Brazilian Amazon presents a wide range of pharmacological actions. This study evaluated the effect of Guarana (Paullinia cupana) extract, pure and dry Guarana (PC-18) extract and magnesium chloride (MgCl2) in mice of the Balb/c strain inoculated with the Ehrlich tumor regarding gene expression of inflammatory markers transforming growth factor-beta 1 and tumor necrosis factor alpha and oxidative stress (OS) and fatigue, superoxide dismutase, catalase, and glutathione peroxidase 4 and analyzed myelotoxicity and hepatotoxicity. After euthanasia, blood was collected to analyze the complete blood count and measured the levels of liver enzymes (alanine aminotransferase and aspartate aminotransferase). Hepatoprotective actions of the crude extract of P. cupana and PC-18 extract were noticed. The PC-18 and MgCl2 group showed the best result regarding animal welfare. There were no associations between compounds and gene expression regarding fatigue and OS. PC-18 reduced the tumor and may have an antitumor action. The crude extract of Guarana presented hepatoprotective action. (AU)

• FAPESP's process: 16/22221-7 - Comparative study between Paullinia cupana, PC-18 and magnesium on the solid Ehrlich tumor: antitumor, antifatigue and antioxidant action analysis
• Grantee: Felipe Ko Chen
• Support Opportunities: Scholarships in Brazil - Scientific Initiation