| Full text | |
| Author(s): Show less - |
Ortiz-Villatoro, Nancy N.
[1]
;
Reyes-Garcia, Selvin Z.
[2]
;
Freitas, Leandro
[1]
;
Rodrigues, Lais D.
[1]
;
Santos, Luiz E. C.
[3]
;
Faber, Jean
[1]
;
Cavalheiro, Esper A.
[1]
;
Finsterer, Josef
[4]
;
Scorza, Fulvio A.
[1]
;
de Almeida, Antonio C. G.
[3]
;
Scorza, Carla A.
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Fed Sao Paulo EPM UNIFESP, Dept Neurol Neurocirurgia, Disciplina Neurociencia, BR-04039032 Sao Paulo - Brazil
[2] Univ Nacl Autonoma Honduras, Fac Ciencias Med, Posgrad Neurol, Tegucigalpa - Honduras
[3] Univ Fed Sao Joao Del Rey, Neurociencia Expt & Computac, Sao Joao Del Rei - Brazil
[4] Mersserli Inst, Krankenanstalt Rudolfstiftung, Vienna - Austria
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 11, n. 1 AUG 18 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
There are no clinical interventions to prevent post-injury epilepsy, a common and devastating outcome after brain insults. Epileptogenic events that run from brain injury to epilepsy are poorly understood. Previous studies in our laboratory suggested Proechimys, an exotic Amazonian rodent, as resistant to acquired epilepsy development in post-status epilepticus models. The present comparative study was conducted to assess (1) stroke-related brain responses 24-h and 30 days after cortical photothrombosis and (2) post-stroke epilepsy between Proechimys rodents and Wistar rats, a traditional animal used for laboratory research. Proechimys group showed smaller volume of ischemic infarction and lesser glial activation than Wistar group. In contrast to Wistar rats, post-stroke decreased levels of pro-inflammatory cytokines and increased levels of anti-inflammatory mediators and growth factors were found in Proechimys. Electrophysiological signaling changes assessed by cortical spreading depression, in vitro and in vivo, showed that Wistar's brain is most severely affected by stroke. Chronic electrocorticographic recordings showed that injury did not lead to epilepsy in Proechimys whereas 88% of the Wistar rats developed post-stroke epilepsy. Science gains insights from comparative studies on diverse species. Proechimys rodents proved to be a useful animal model to study antiepileptogenic mechanisms after brain insults and complement conventional animal models. (AU) | |
| FAPESP's process: | 16/06879-2 - Brain dynamics after stroke in a rodent from the Amazon rainforest |
| Grantee: | Carla Alessandra Scorza Bahi |
| Support Opportunities: | Regular Research Grants |