Heparan sulfate fine-tunes stromal-epithelial communication in the prostate gland

Author(s)

Barbosa, Guilherme O. ^[1] ; Biancardi, Manoel F. ^[2] ; Carvalho, Hernandes F. ^[1]

Affiliation

^[1] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Campinas - Brazil

^[2] Univ Fed Goias, Inst Biol Sci, Dept Histol Embryol & Cell Biol, Goiania, Go - Brazil

• Document type: Review article
• Source: DEVELOPMENTAL DYNAMICS; v. 250, n. 5, p. 618-628, MAY 2021.
• Web of Science Citations: 1

Abstract

Several studies reported the concerted and mutual communication between the prostate epithelium and stroma, which determines the final organ architecture and function, but gets awry in cancer. Deciphering the mechanisms involved in this communication is crucial to find new therapeutic strategies. HS sequesters a number of secreted growth factors and cytokines, controlling their bioavailability to the target cells, suggesting that HS is an important regulator of the extracellular matrix (ECM) and a key player in the cell-cell and cell-microenvironment communication during prostate morphogenesis and physiology. We propose that by controlling HS biosynthesis and sulfation pattern, as well as the cleavage of the HS chain and/or the shedding of proteoglycans, epithelial and stromal cells are able to precisely tune the availability of signaling molecules and modulate ligand-receptor interaction and intracellular signal transduction. (AU)

• FAPESP's process: 09/16150-6 - Androgen regulation, sinalization and cellular interactions in prostate development, physiology and regression
• Grantee: Hernandes Faustino de Carvalho
• Support Opportunities: Research Projects - Thematic Grants