lusters of Double Triggering Impact Clinical Outcomes: Insights From the EPIdemiology of Patient-Ventilator aSYNChrony (EPISYNC) Cohort Stud

Author(s)

Sousa, Mayson Laerciod E. Araujo ^{[1, 2, 3]} ; Magrans, Rudys ^{[4, 1, 5]} ; Hayashi, Fatima K. ^{[1, 2, 3]} ; Blanch, Lluis ^{[4, 1, 5]} ; Kacmarek, Robert M. ^{[1, 6, 7]} ; Ferreira, Juliana C. ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Hosp Clin, Inst Coracao, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Hosp Clin, Inst Coracao, Div Pneumol, Fac Med, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, Hosp Clin, Inst Coracao, Serv Fisioterapia, Sao Paulo - Brazil

^[4] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp, Madrid - Spain

^[5] Univ Autonoma Barcelona, Crit Care Ctr, Hosp Univ Parc Tauli, Inst Invest & Innovacio Parc Tauli I3PT, Sabadell - Spain

^[6] Harvard Med Sch, Massachusetts Gen Hosp, Dept Resp Care, Boston, MA 02115 - USA

^[7] Harvard Med Sch, Massachusetts Gen Hosp, Dept Anesthesiol, Boston, MA 02115 - USA

• Document type: Journal article
• Source: Critical Care Medicine; v. 49, n. 9, p. 1460-1469, SEP 2021.
• Web of Science Citations: 2

Abstract

OBJECTIVES: To measure the impact of clusters of double triggering on clinical outcomes. DESIGN: Prospective cohort study. SETTING: Respiratory ICU in Brazil. PATIENTS: Adult patients under recent mechanical ventilation and with expectation of mechanical ventilation for more than 24 hours after enrollment. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We used a dedicated software to analyze ventilator waveforms throughout the entire period of mechanical ventilation and detect double triggering. We defined a cluster of double triggering as a period of time containing at least six double triggering events in a 3-minute period. Patients were followed until hospital discharge. We addressed the association between the presence and the duration of clusters with clinical outcomes. A total of 103 patients were enrolled in the study and 90 (87%) had at least one cluster of double triggering. The median number of clusters per patient was 19 (interquartile range, 6-41), with a median duration of 8 minutes (6-12 min). Compared with patients who had no clusters, patients with at least one cluster had longer duration of mechanical ventilation (7 d {[}4-11 d] vs 2 d {[}2-3 d]) and ICU length of stay (9 d {[}7-16 d] vs 13 d {[}2-8 d]). Thirty-three patients had high cumulative duration of clusters of double triggering (>= 12 hr), and it was associated with longer duration of mechanical ventilation, fewer ventilator-free days, and longer ICU length of stay. Adjusted by duration of mechanical ventilation and severity of illness, high cumulative duration of clusters was associated with shorter survival at 28 days (hazard ratio, 2.09 d; 95% CI, 1.04-4.19 d). CONCLUSIONS: Clusters of double triggering are common and were associated with worse clinical outcomes. Patients who had a high cumulative duration of clusters had fewer ventilator-free days, longer duration of mechanical ventilation, longer ICU length of stay, and shorter survival than patients with low cumulative duration of cluster. (AU)

• FAPESP's process: 15/19122-4 - Relationship between respiratory mechanics and patient-ventilator asynchrony index in patients with invasive mechanical ventilation
• Grantee: Juliana Carvalho Ferreira
• Support Opportunities: Regular Research Grants