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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Efficacy of Gene Therapy to Restore Cognition in Alzheimer's Disease: A Systematic Review

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Author(s):
Tedeschi, V, Desyrre ; da Cunha, Anderson F. [1] ; Cominetti, Marcia R. [2] ; Pedroso, Renata Valle [2]
Total Authors: 4
Affiliation:
[1] Univ Fed Sao Carlos, Dept Genet & Evolut, Rodovia Washington Luis Km 310, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Gerontol, Rodovia Washington Luis Km 310, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: CURRENT GENE THERAPY; v. 21, n. 3, p. 246-257, 2021.
Web of Science Citations: 0
Abstract

Background: Alzheimer's disease (AD) is the main cause of dementia and it is a progressive neurogenerative disease characterized by the accumulation of neurofibrillary tangles and senile plaques. There is currently no cure; however, some treatments are available to slow down the progression of the disease, including gene therapy, which has been investigated to have great potential for the treatment of AD. Objective: The aim of this review was to identify the efficacy of gene therapy to restore cognition in AD. Methods: A systematic review was carried out using papers published up to May 2020 and available in the Web of Science, Scopus, and Medline/PUBMED databases. Articles were considered for inclusion if they were original researches that investigated the effects of gene therapy on cognition in AD. The methodological quality of the selected studies was evaluated using the Risk of Bias Tool for Animal Intervention Studies (SYRCLE's Rob tool) and the Jadad Scale. Results: Most preclinical studies obtained positive results in improving memory and learning in mice that underwent treatment with gene therapy. On the other hand, clinical studies have obtained inconclusive results related to the delivery methods of the viral vector used in gene therapy. Conclusion: Gene therapy has shown a great potential for the treatment of AD in preclinical trials, but results should be interpreted with caution since preclinical studies presented limitations to predict the efficacy of the treatment outcome in humans. (AU)

FAPESP's process: 17/18808-5 - Influence of APOE genotype and neurotrophic factors on event related potentials (ERP-P300) of elderly with Alzheimer's Disease and healthy elderly
Grantee:Renata Valle Pedroso
Support Opportunities: Scholarships in Brazil - Post-Doctoral