Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg-Al]-layered double hydroxide as an antimicrobial wound dressing

Author(s)

Malafatti, Joao O. D. ^{[1, 2]} ; Bernardo, Marcela P. ^[1] ; Moreira, Francys K. V. ^[3] ; Ciol, Heloisa ^[4] ; Inada, Natalia M. ^[4] ; Mattoso, Luiz H. C. ^[1] ; Paris, Elaine C. ^[1]

Affiliation

^[1] Embrapa Instrumentacao, LNNA, 1452 15 Novembro St, BR-13560970 Sao Carlos - Brazil

^[2] Univ Fed Sao Carlos, Dept Chem, Sao Carlos - Brazil

^[3] Univ Fed Sao Carlos, Dept Mat Engn, Sao Carlos - Brazil

^[4] Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos - Brazil

• Document type: Journal article
• Source: POLYMERS FOR ADVANCED TECHNOLOGIES; v. 31, n. 6, p. 1377-1387, JUN 2020.
• Web of Science Citations: 7

Abstract

Poly(lactic acid) (PLA) is a versatile, bioabsorbable, and biodegradable polymer with excellent biocompatibility and ability to incorporate a great variety of active agents. Silver sulfadiazine (SDZ) is an antibiotic used to control bacterial infection in external wounds. Aiming to combine the properties of PLA and SDZ, hydrotalcite ({[}Mg-Al]-LDH) was used as a host matrix to obtain an antimicrobial system efficient in delivering SDZ from electrospun PLA scaffolds intended for wound skin healing. The structural reconstruction method was successfully applied to intercalate silver sulfadiazine in the {[}Mg-Al]-LDH, as evidenced by X-ray diffraction and thermogravimetric analyses. Observations by scanning electron microscopy revealed a good distribution of SDZ-{[}Mg-Al]-LDH within the PLA scaffold. Kinetics studies revealed a slow release of SDZ from the PLA scaffold due to the intercalation in the {[}Mg-Al]-LDH. In vitro antimicrobial tests indicated a significant inhibitory effect of SDZ-{[}Mg-Al]-LDH against Escherichia coli and Staphylococcus aureus. This antibacterial activity was sustained in the 2.5-wt% SDZ-{[}Mg-Al]-LDH-loaded PLA nanofibers, which also displayed excellent biocompatibility towards human cells. The multifunctionality of the PLA/SDZ-{[}Mg-Al]-LDH scaffold reported here is of great significance for various transdermal applications. (AU)

• FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 18/07860-9 - Development of nanocomposite polymer filaments with anti-inflammatory properties for 3D printing as bone substituent
• Grantee: Marcela Piassi Bernardo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral