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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cellulose nanocrystals-based materials as hemostatic agents for wound dressings: a review

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Author(s):
Cidreira, Anne Carolyne Mendonca [1] ; de Castro, Karine Cappuccio [1] ; Hatami, Tahmasb [1] ; Linan, Lamia Zuniga [2] ; Mei, Lucia Helena Innocentini [1]
Total Authors: 5
Affiliation:
[1] Univ Campinas UNICAMP, Dept Mat Engn & Bioproc, Sch Chem Engn FEQ, BR-13083970 Campinas, SP - Brazil
[2] Fed Univ Maranhao UFMA, Chem Engn Dept DEEQ, Lab Mat & Proc Engn LaMEP, Av Portugueses 1933, BR-65080805 Sao Luis, MA - Brazil
Total Affiliations: 2
Document type: Review article
Source: BIOMEDICAL MICRODEVICES; v. 23, n. 4 DEC 2021.
Web of Science Citations: 0
Abstract

Wound dressings are devices used to stop bleeding and provide appropriate environmental conditions to accelerate wound healing. The effectiveness of wound dressing materials can be crucial to prevent deaths from excessive bleeding in surgeries and promote complete restoration of the injury. Some requirements for an ideal wound dressing are rapid hemostatic effect, high swelling capacity, antibacterial properties, biocompatibility, biodegradability, and mechanical strength. However, finding all these properties in a single material remains a challenge. In this context, nanocomposites have demonstrated an excellent capacity for this application because of their multifunctionality. One of the emerging materials used in nanocomposite manufacture is cellulose nanocrystals (CNCs), which are rod-like crystalline nanometric structures present on cellulose chains. These nanoparticles are attractive for wound healing applications because of their high aspect ratio, high mechanical properties, functionality and low density. Hence, this work aimed to present an overview of nanocomposites constituted by CNCs for wound healing applications. The review focuses on the most common materials used as matrices, the types of dressing, and their fabrication techniques. Novel wound dressings composites have improved hemostatic, swelling, and mechanical properties compared to other pure biopolymers while preserving their other biological properties. Films, nanofibers mats, sponges, and hydrogels have been prepared with CNCs nanocomposites, and in vitro and in vivo tests have proved their suitability for wound healing. (AU)

FAPESP's process: 18/18722-6 - Constructing a supercritical deposition-foaming unit for 3D supports (scaffold) fabrication: Experiment, mathematical modeling, and optimization
Grantee:Tahmasb Hatami
Support Opportunities: Scholarships in Brazil - Post-Doctoral