Influence of motor impairment on exercise capacity and quality of life in patients with Parkinson disease

Author(s)

Kanegusuku, Helcio ^[1] ; Ritti-Dias, Raphael M. ^[2] ; Barbosa, Pamela Yuki Igarasi ^{[3, 4]} ; Guelfi, Erica Tardelli das Neves ^[4] ; Okamoto, Erika ^[4] ; Miranda, Camila Souza ^[3] ; Oliveira, Tatiana de Paula ^[3] ; Piemonte, Maria Elisa Pimentel ^[3]

Affiliation

^[1] Hosp Israelita Albert Einstein, Av Albert Einstein 627-701, BR-05651901 Sao Paulo - Brazil

^[2] Univ Nove Julho, Grad Program Rehabil Sci, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med Sci, Sao Paulo - Brazil

^[4] Brazil Parkinson Assoc, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF EXERCISE REHABILITATION; v. 17, n. 4, p. 241-246, AUG 2021.
• Web of Science Citations: 0

Abstract

This study evaluated the impact of motor impairment (MI) on exercise capacity and quality of life in patients with Parkinson disease (PD). One hundred ninety-two patients (>= 50 years old) were divided according to the Hoehn and Yahr stages in: mild (stage I), mild to moderate (stage II), moderate (stage III), and advanced MI (stage IV). Exercise capacity (6-min walk test {[}6MWT]) and quality of life (Parkinson's Disease Questionnaire {[}PDQ-39]) were obtained. In this context, 6MWT was progressively worse with increasing the severity of MI (P<0.01). Patients with advanced MI achieved 39% of predicted 6MWT of healthy subject, while subjects with mild MI achieved 83% of healthy subject (P<0.01). In addition, patients with advanced MI presented higher (i.e., worse) PDQ-39 scores in summary index, cognition, mobility and activities of daily live domains compared to other groups (P<0.01). Patients with moderate MI also presented worse scores in PDQ-39 summary index, mobility and activities of daily live domains in comparison with mild MI patients (P<0.01). Higher MI was correlated with worse exercise capacity (6MWT: r=-0.46, P<0.01), with worse PDQ-39 summary index and the mobility and activities of daily live domains scores (r=0.38, r=0.46, and r=0.43, P<0.01). In conclusion, MI is related to lower exercise capacity and quality of life (i.e., PDQ-39 summary index and mobility and activities of daily live domains) in patients with PD. (AU)

• FAPESP's process: 13/07699-0 - Research, Innovation and Dissemination Center for Neuromathematics - NeuroMat
• Grantee: Oswaldo Baffa Filho
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC