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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

he Crosstalk between Melatonin and Sex Steroid Hormone

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Author(s):
Cipolla-Neto, Jose [1] ; Amaral, Fernanda Gaspar [2] ; Soares-Jr, Jose Maria ; Gallo, Camila Congentino [2] ; Furtado, Andre [3] ; Cavaco, Jose Eduardo [3] ; Goncalves, Isabel [3] ; Alves Santos, Cecilia Reis [3] ; Quintela, Telma [3]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil
[3] Univ Beira Interior, CICS UBI Hlth Sci Res Ctr, Covilha - Portugal
Total Affiliations: 3
Document type: Review article
Source: Neuroendocrinology; v. 112, n. 2 MAR 2021.
Web of Science Citations: 5
Abstract

Melatonin, an indolamine mainly released from the pineal gland, is associated with many biological functions, namely, the modulation of circadian and seasonal rhythms, sleep inducer, regulator of energy metabolism, antioxidant, and anticarcinogenic. Although several pieces of evidence also recognize the influence of melatonin in the reproductive physiology, the crosstalk between melatonin and sex hormones is not clear. Here, we review the effects of sex differences in the circulating levels of melatonin and update the current knowledge on the link between sex hormones and melatonin. Furthermore, we explore the effects of melatonin on gonadal steroidogenesis and hormonal control in females. The literature review shows that despite the strong evidence that sex differences impact on the circadian profiles of melatonin, reports are still considerably ambiguous, and these differences may arise from several factors, like the use of contraceptive pills, hormonal status, and sleep deprivation. Furthermore, there has been an inconclusive debate about the characteristics of the reciprocal relationship between melatonin and reproductive hormones. In this regard, there is evidence for the role of melatonin in gonadal steroidogenesis brought about by research that shows that melatonin affects multiple transduction pathways that modulate Sertoli cell physiology and consequently spermatogenesis, and also estrogen and progesterone production. From the outcome of our research, it is possible to conclude that understanding the correlation between melatonin and reproductive hormones is crucial for the correction of several complications occurring during pregnancy, like preeclampsia, and for the control of climacteric symptoms. (AU)

FAPESP's process: 14/50457-0 - Melatonin and the control of energy metabolism: basic, clinical and epidemiological research
Grantee:José Cipolla Neto
Support Opportunities: Research Projects - Thematic Grants