Sub-lethal combined effects of illicit drug and decreased pH on marine mussels: A short-time exposure to crack cocaine in CO2 enrichment scenarios

Author(s):Show less -

da Silva Souza, Lorena ^[1] ; Bonnail, Estefania ^[2] ; Alves Maranho, Luciane ^[3] ; Hermes Pusceddu, Fabio ^[3] ; Cortez, Fernando Sanzi ^[3] ; Cesar, Augusto ^{[4, 3]} ; Ribeiro, Daniel Araki ^[4] ; Riba, Inmaculada ^[1] ; de Souza Abessa, Denis M. ^[5] ; DelValls, Angel ^[3] ; Seabra Pereira, Camilo Dias ^{[4, 3]}

Affiliation

^[1] Univ Cadiz, Fac Marine & Environm Sci, Dept Phys Chem, Aquat Syst Res Grp, UNESCO UNITWIN WiCop, Cadiz - Spain

^[2] Univ Atacama, Ctr Invest Costeras, Copiapo - Chile

^[3] Santa Cecilia Univ UNISANTA, Dept Ecotoxicol, Santos, SP - Brazil

^[4] Fed Univ Sao Paulo UNIFESP, Dept Marine Sci, Santos, SP - Brazil

^[5] Paulista State Univ UNESP, Study Ctr Pollut & Aquat Ecotoxicol, Sao Vicente, SP - Brazil

• Document type: Journal article
• Source: Marine Pollution Bulletin; v. 171, OCT 2021.
• Web of Science Citations: 0

Abstract

The increasing CO2-concentrations in the atmosphere promote ocean acidification. Seawater chemistry changes interact with contaminants, such as illicit drugs in the coastal zones. This work evaluates impacts of pH decrease and crack-cocaine exposure on the commercial mussel Perna perna through biomarker responses (lysosomal membrane stability, lipid peroxidation, and DNA strand breaks). The organisms were exposed to different crack-cocaine concentrations (0.5, 5.0, and 50 mu g L-1) combined with different pH values (8.3, 8.0, 7.5, 7.0, 6.5, and 6.0) for 96 h. Crack-cocaine in the different acidification scenarios triggered cyto-genotoxicity, which affected the overall health of mussels exposed to cocaine environmentally relevant concentration. This study produced the first data on biomarker responses associated with CO2-induced acidification and illicit drugs (crack-cocaine) in marine organisms. (AU)

• FAPESP's process: 18/18456-4 - EVALUATION OF TOXICITY OF CRACK/COCAINE TO MARINE ORGANISMS EXPOSED TO DIFFERENT SCENARIOS OF ACIDIFICATION BY ENRICHMENT OF CO2.
• Grantee: Tomas Angel Del Valls Casillas
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/25936-0 - Evaluation of toxicity of crack-cocaine to marine mussels exposed to different scenarios of acidification of global change: ToxCO2caine
• Grantee: Camilo Dias Seabra Pereira
• Support Opportunities: Research Grants - Visiting Researcher Grant - International