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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Radiation interaction with DNA

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Author(s):
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A. Deppman [1] ; J.O. Echeimberg [2] ; A.N. Gouveia ; J.D.T. Arruda-Neto ; F.M. Milian ; N. Added [6] ; M.E. Camargo [7] ; F. Guzman [8] ; O.A.M. Helene [9] ; V.P. Likhachev [10] ; O. Rodriguez [11] ; A.C.G. Schenberg [12] ; V. Vanin [13] ; E.J. Vicente [14]
Total Authors: 14
Affiliation:
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[1] Universidade de São Paulo. Instituto de Física - Brasil
[2] Universidade de São Paulo. Instituto de Física - Brasil
[6] Universidade de São Paulo. Instituto de Física - Brasil
[7] Universidade de São Paulo. Instituto de Ciências Biomédicas - Brasil
[8] Instituto Superior de Ciencias e Tecnologias Nucleares - Cuba
[9] Universidade de São Paulo. Instituto de Física - Brasil
[10] Universidade de São Paulo. Instituto de Física - Brasil
[11] Instituto Superior de Ciencias e Tecnologias Nucleares - Cuba
[12] Universidade de São Paulo. Instituto de Ciências Biomédicas - Brasil
[13] Universidade de São Paulo. Instituto de Física - Brasil
[14] Universidade de São Paulo. Instituto de Ciências Biomédicas - Brasil
Total Affiliations: 14
Document type: Journal article
Source: Brazilian Journal of Physics; v. 34, p. 958-961, 2004-09-00.
Field of knowledge: Biological Sciences - Biophysics
Abstract

We developed a model to describe the radiation-DNA interaction in water solution. The model is based on some important aspects of the Bethe Theory for the ionizing process, and on the assumption that the direct interaction between the incident particle and the DNA molecule is negligible in comparison with the indirect effect. This assumption can always be true under controlled conditions. The results show that the number of damages induced by radiation depends on the accumulated dose, on parameters related only to the medium properties, and on the DNA structure, but not on the incident particle. A few applications of the model are discussed, and results are successfully compared with experimental data. New experiments are proposed. (AU)