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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cholesterol modulates the interaction between paclitaxel and Langmuir monolayers simulating cell membranes

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Author(s):
Pereira, Andressa R. [1] ; Shimizu, Flavio M. [2] ; Oliveira Jr, Osvaldo N.
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Sao Carlos Inst Phys, Sao Paulo, SP - Brazil
[2] Univ Campinas UNICAMP, Gleb Wataghin Inst Phys IFGW, Dept Appl Phys, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: COLLOIDS AND SURFACES B-BIOINTERFACES; v. 205, SEP 2021.
Web of Science Citations: 0
Abstract

The composition of Langmuir monolayers used as cell membrane models is an essential factor for the interaction with biologically-relevant molecules, including pharmaceutical drugs. In this paper, we report the modulation of effects from the antineoplastic drug paclitaxel by the relative concentration of cholesterol in the Langmuir monolayers of ternary mixtures of dipalmitoylphosphatidylcholine, sphingomyelin, and cholesterol. Since the dependence on cholesterol concentration for these monolayers simulating lipid rafts is non-monotonic, we analyzed the surface pressure and compressibility modulus data with the multidimensional projection technique referred to as interactive document mapping (IDMAP). The maximum expansion induced by paclitaxel in surface pressure isotherms was observed for 27% cholesterol, while the compressibility modulus decreased most strongly for the monolayer with 48% cholesterol. Therefore, the physiological action of paclitaxel may vary depending on whether it is associated with penetration in the membrane or with changes in the membrane elasticity. (AU)

FAPESP's process: 18/00878-0 - Study of lipid rafts through the interaction between membrane models and chitosan and cholesterol oxidase
Grantee:Andressa Ribeiro Pereira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis
Grantee:Osvaldo Novais de Oliveira Junior
Support Opportunities: Research Projects - Thematic Grants