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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

68Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake

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Author(s):
Matheus Zanelatto Junqueira [1] ; Nelisa Helena Rocha [2] ; Marcelo Tatit Sapienza [3]
Total Authors: 3
Affiliation:
[1] Universidade de São Paulo. Faculdade de Medicina - Brasil
[2] Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira - Brasil
[3] Universidade de São Paulo. Faculdade de Medicina - Brasil
Total Affiliations: 3
Document type: Journal article
Source: Radiologia Brasileira; v. 54, n. 3, p. 171-176, 2021-05-24.
Abstract

Abstract Objective: To evaluate the effect that external cooling of the salivary glands (ECSG) has on the uptake of gallium-68-labeled prostate-specific membrane antigen (68Ga-PSMA), as an indirect assessment of the capacity of ECSG to reduce the local dose in lutetium-177-PSMA-617 radioligand therapy. Materials and Methods: Ten patients with prostate cancer were submitted to 68Ga-PSMA positron emission tomography/computed tomography with unilateral ECSG. The ECSG was started at 30 min before the injection of the radiotracer and maintained until the end of image acquisition (1 h after injection). Each salivary gland was assessed by determining the maximum, mean, and peak standardized uptake values (SUVmax, SUVmean, and SUVpeak, respectively). The volume of each gland was determined in a volume of interest delineated by a threshold SUVmax of 10%. Paired Student’s t-tests were used in order to compare the results. Results: In terms of the SUV parameters, there were no statistically significant differences between the cooled and contralateral salivary glands. However, the mean volume was 27% lower in the cooled parotid glands than in the contralateral parotid glands (p = 0.004). Conclusion: The use of ECSG does not appear to reduce 68Ga-PSMA uptake by the salivary glands. In addition, there is yet no evidence that ECSG is effective in preventing salivary gland toxicity. (AU)

FAPESP's process: 19/00808-4 - Effect of cervical skin cooling in the reduction of 68GaPSMA uptake in salivary glands of patients with prostate cancer
Grantee:Matheus Zanelatto Junqueira
Support Opportunities: Scholarships in Brazil - Scientific Initiation