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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Understanding the Renal Fibrotic Process in Leptospirosis

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Author(s):
Prado, Luan Gaviao ; Barbosa, Angela Silva
Total Authors: 2
Document type: Review article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 19 OCT 2021.
Web of Science Citations: 0
Abstract

Leptospirosis is a neglected infectious disease caused by pathogenic species of the genus Leptospira. The acute disease is well-described, and, although it resembles other tropical diseases, it can be diagnosed through the use of serological and molecular methods. While the chronic renal disease, carrier state, and kidney fibrosis due to Leptospira infection in humans have been the subject of discussion by researchers, the mechanisms involved in these processes are still overlooked, and relatively little is known about the establishment and maintenance of the chronic status underlying this infectious disease. In this review, we highlight recent findings regarding the cellular communication pathways involved in the renal fibrotic process, as well as the relationship between renal fibrosis due to leptospirosis and CKD/CKDu.</p> (AU)

FAPESP's process: 21/01122-9 - Renal pathological aspects related to persistence and chronic infection by Leptospira interrogans
Grantee:Angela Silva Barbosa
Support Opportunities: Regular Research Grants