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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Echocardiographic Assessment of Healthy Midazolam/Butorphanol or Midazolam/Morphine-Sedated Dogs

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Author(s):
Possidonio, Geovana [1] ; Santos, Caroliny A. [1] ; Ferreira, Mariana A. [1] ; Floriano, Beatriz P. [1] ; de Almeida, Breno F. M. [1] ; Marques, Ana Elisa G. W. [2] ; Marques, Marcel G. [1]
Total Authors: 7
Affiliation:
[1] Univ Ctr Integrated Coll Ourinhos UNIFIO, Dept Vet Med, Ourinhos, SP - Brazil
[2] MSC, DVM, Ourinhos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: TOPICS IN COMPANION ANIMAL MEDICINE; v. 45, NOV 2021.
Web of Science Citations: 1
Abstract

The purpose of this study was to assess the effects of midazolam combined with morphine or butorphanol on echocardiographic variables of healthy dogs. Twenty-four dogs of various breeds aged 34.33 +/- 23.41 months and weighing 8.1 +/- 4.7 kg were enrolled in the study. Subjects were randomly allocated in one of two experimental groups of sedation with intramuscular midazolam (0.3 mg/kg) combined with butorphanol (0.2 mg/ kg) (G(B), n = 12) or morphine (0.3 mg/kg) (G(M), n = 12). Transthoracic echocardiographic examinations comprised B-Mode, M-Mode, spectral Doppler and pulsed tissue Doppler assessment. Data were recorded before sedation (T-B) and 20 minutes following intramuscular administration of either sedation protocol (T-S). Data were analyzed using repeated measures ANOVA followed by Tukey's posthoc test. Shortening fraction, ejection fraction, left ventricular diameter and volume did not differ among groups and time points. The A and E' waves were decreased in G(M) at T-S compared to T-B. Isovolumic relaxation time, Ae/Ao ratio, aortic and pulmonary flows and S' wave did not differ among time points and groups. These sedation protocols did not cause clinically relevant changes in echocardiographic variables, therefore can be used for sedation of uncooperative dogs during echocardiographic evaluation. (C) 2021 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 18/23415-5 - Echocardiographic assessment of healthy dogs sedated with midazolam/butorphanol or midazolam/morphine
Grantee:Geovana Possidonio
Support Opportunities: Scholarships in Brazil - Scientific Initiation