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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multidrug-resistant Trichosporon species: underestimated fungal pathogens posing imminent threats in clinical settings

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Author(s):
Arastehfar, Amir [1] ; de Almeida Junior, Joao N. [2, 3] ; Perlin, David S. [1] ; Ilkit, Macit [4] ; Boekhout, Teun [5, 6] ; Colombo, Arnaldo Lopes [7]
Total Authors: 6
Affiliation:
[1] Hackensack Meridian Hlth, Ctr Discovery & Innovat, Nutley, NJ 07110 - USA
[2] Univ Sao Paulo, Inst Med Trop, Lab Micol Med LIM 53, Sao Paulo - Brazil
[3] Univ Sao Paulo, Hosp Clin, Fac Med, Lab Cent LIM 03, Sao Paulo - Brazil
[4] Univ Cukurova, Div Mycol, Adana - Turkey
[5] Westerdijk Fungal Biodivers Inst, Utrecht - Netherlands
[6] Univ Amsterdam, Inst Biodivers & Ecosyst Dynam IBED, Amsterdam - Netherlands
[7] Univ Fed Sao Paulo, Escola Paulista Med, Div Infect Dis, Dept Med, Sao Paulo - Brazil
Total Affiliations: 7
Document type: Review article
Source: CRITICAL REVIEWS IN MICROBIOLOGY; v. 47, n. 6, p. 679-698, NOV 2 2021.
Web of Science Citations: 2
Abstract

Species of Trichosporon and related genera are widely used in biotechnology and, hence, many species have their genome sequenced. Importantly, yeasts of the genus Trichosporon have been increasingly identified as a cause of life-threatening invasive trichosporonosis (IT) in humans and are associated with an exceptionally high mortality rate. Trichosporon spp. are intrinsically resistant to frontline antifungal agents, which accounts for numerous reports of therapeutic failure when echinocandins are used to treat IT. Moreover, these fungi have low sensitivity to polyenes and azoles and, therefore, are potentially regarded as multidrug-resistant pathogens. However, despite the clinical importance of Trichosporon spp., our understanding of their antifungal resistance mechanisms is quite limited. Furthermore, antifungal susceptibility testing is not standardized, and there is a lack of interpretive epidemiological cut-off values for minimal inhibitory concentrations to distinguish non-wild type Trichosporon isolates. The route of infection remains obscure and detailed clinical and environmental studies are required to determine whether the Trichosporon infections are endogenous or exogenous in nature. Although our knowledge on effective IT treatments is rather limited and future randomized clinical trials are required to identify the best antifungal agent, the current paradigm advocates the use of voriconazole, removal of central venous catheters and recovery from neutropenia. (AU)

FAPESP's process: 18/19347-4 - Characterization of molecular mechanisms related to azoles resistance in Trichosporon asahii clinical isolates
Grantee:João Nóbrega de Almeida Júnior
Support Opportunities: Scholarships abroad - Research