| Full text | |
| Author(s): |
Bianco, Bianca
[1, 2]
;
Loureiro, Flavia Altheman
[1]
;
Trevisan, Camila Martins
[1]
;
Peluso, Carla
[1]
;
Christofolini, Denise Maria
[1]
;
Montagna, Erik
[3]
;
Lagana, Antonio Simone
[4]
;
Barbosa, Caio Parente
[1]
Total Authors: 8
|
| Affiliation: | [1] Ctr Univ FMABC, Dept Collect Hlth, Discipline Sexual & Reprod Hlth & Populat Genet, Fac Med ABC, Santo Andre, SP - Brazil
[2] Inst Israelita Ensino & Pesquisa Albert Einstein, Dept Urol, Sao Paulo - Brazil
[3] Ctr Univ FMABC, Postgrad Program Hlth Sci, Fac Med ABC, Santo Andre, SP - Brazil
[4] Univ Insubria, Filippo Del Ponte Hosp, Dept Obstet & Gynecol, Varese - Italy
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | FRONTIERS IN ENDOCRINOLOGY; v. 12, SEP 30 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Background Single nucleotide variants (SNVs) FSHB:c.-211G>T, FSHR:c.919G>A, and FSHR:c.2039G>A were reported to be associated with the variability in FSH and LH levels, and in vitro fertilization (IVF) outcomes. In this study, we aimed to evaluate the effects of FSHB:c.-211G>T, FSHR:c.919G>A, and FSHR:c.2039G>A variants, alone and combined, on the hormonal profile and reproduction outcomes of women with endometriosis.</p> Methods A cross-sectional study was performed comprising 213 infertile Brazilian women with endometriosis who underwent IVF treatment. Genotyping was performed using TaqMan real-time PCR. Variables were compared according to the genotypes of each variant and genetic models, and the combined effects of the SNVs were evaluated using the multifactorial dimensionality reduction method.</p> Results FSHB:c.-211G>T affected LH levels in women with overall endometriosis and minimal/mild disease. FSHR:c.919G>A affected FSH levels in women with overall endometriosis and the number of oocytes retrieved in those with moderate/severe endometriosis. Moreover, the FSHR:c.2039G>A affected FSH levels in women with overall endometriosis, LH levels and total amount of rFSH in those with minimal/mild disease, and number of follicles and number of oocytes retrieved in those with moderate/severe endometriosis. No effect on hormone profile or reproductive outcomes was observed when the genotypes were combined.</p> Conclusions Variants of the FSHB and FSHR genes separately interfered with the hormonal profiles and IVF outcomes of women with endometriosis.</p> (AU) | |
| FAPESP's process: | 16/25953-9 - Evaluation of mutations and/or polymorphisms in candidate genes by next generation sequence in infertile women with and without endometriosis and its correlation with results of controlled ovarian hyperstimulation in assisted human reproduction treatments |
| Grantee: | Bianca Alves Vieira Bianco |
| Support Opportunities: | Regular Research Grants |