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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Off balance: Interferons in COVID-19 lung infections

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Author(s):
Akamatsu, Milena [1] ; de Castro, Tavares [1] ; Takano, Carolina Yumi [1] ; Ho, Paulo Lee [1]
Total Authors: 4
Affiliation:
[1] Inst Butantan, Ctr BioInd, Nucleo Prod Vacinas Bacterianas, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: EBIOMEDICINE; v. 73, NOV 2021.
Web of Science Citations: 0
Abstract

Interferons are innate and adaptive cytokines involved in many biological responses, in particular, viral infections. With the final response the result of the balance of the different types of Interferons. Cytokine storms are physiological reactions observed in humans and animals in which the innate immune system causes an uncontrolled and excessive release of pro-inflammatory signaling molecules. The excessive and prolonged presence of these cytokines can cause tissue damage, multisystem organ failure and death. The role of Interferons in virus clearance, tissue damage and cytokine storms are discussed, in view of COVID-19 caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The imbalance of Type I, Type II and Type III Interferons during a viral infection contribute to the clinical outcome, possibly together with other cytokines, in particular, TNFa, with clear implications for clinical interventions to restore their correct balance. (C) 2021 The Author(s). Published by Elsevier B.V. (AU)

FAPESP's process: 20/07040-1 - Center of Research and Development in Immunobiologicals
Grantee:Ana Maria Moro
Support Opportunities: Research Grants - Problem-Oriented Research Centers in São Paulo