The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers

Author(s):Show less -

Freitas, Lucas F. ^[1] ; Ferreira, Aryel H. ^{[2, 1]} ; Thipe, Velaphi C. ^[1] ; Varca, Gustavo H. C. ^[1] ; Lima, Caroline S. A. ^[1] ; Batista, Jorge G. S. ^[1] ; Riello, Fabiane N. ^[1] ; Nogueira, Kamila ^[1] ; Cruz, Cassia P. C. ^[1] ; Mendes, Giovanna O. A. ^[1] ; Rodrigues, Adriana S. ^[1] ; Sousa, Thayna S. ^[1] ; Alves, Victoria M. ^[1] ; Lugao, Ademar B. ^[1]

Affiliation

^[1] IPEN CNEN SP, Nucl & Energy Res Inst, BR-05508000 Sao Paulo - Brazil

^[2] Univ Prebiteriana Mackenzie, MackGraphe Graphene & Nanomat Res Ctr, BR-01302907 Sao Paulo - Brazil

• Document type: Review article
• Source: NANOMATERIALS; v. 11, n. 10 OCT 2021.
• Web of Science Citations: 1

Abstract

The synthesis and engineering of nanomaterials offer more robust systems for the treatment of cancer, with technologies that combine therapy with imaging diagnostic tools in the so-called nanotheranostics. Among the most studied systems, there are quantum dots, liposomes, polymeric nanoparticles, inorganic nanoparticles, magnetic nanoparticles, dendrimers, and gold nanoparticles. Most of the advantages of nanomaterials over the classic anticancer therapies come from their optimal size, which prevents the elimination by the kidneys and enhances their permeation in the tumor due to the abnormal blood vessels present in cancer tissues. Furthermore, the drug delivery and the contrast efficiency for imaging are enhanced, especially due to the increased surface area and the selective accumulation in the desired tissues. This property leads to the reduced drug dose necessary to exert the desired effect and for a longer action within the tumor. Finally, they are made so that there is no degradation into toxic byproducts and have a lower immune response triggering. In this article, we intend to review and discuss the state-of-the-art regarding the use of nanomaterials as therapeutic and diagnostic tools for lung, breast, and prostate cancer, as they are among the most prevalent worldwide.</p> (AU)

• FAPESP's process: 18/15598-2 - Tumor ablation using ionizing radiation and Pd and Au nanoparticles in Melanoma and Hepatocellular Carcinoma in vitro and in vivo
• Grantee: Lucas Freitas de Freitas
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/01315-1 - Development of nanostructured systems to increase the efficacy of chemotherapy and immunotherapy for Bladder Cancer
• Grantee: Caroline Santos Alves de Lima
• Support Opportunities: Scholarships in Brazil - Doctorate