ZIKV Infection and miRNA Network in Pathogenesis and Immune Response

Author(s)

Polonio, Carolina Manganeli ^{[1, 2]} ; Peron, Jean Pierre Schatzmann ^{[1, 2, 3]}

Affiliation

^[1] Univ Sao Paulo, Dept Immunol, Neuroimmune Interact Lab, BR-05508000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sci Platform Pasteur USP SPPU, Lab Neuroimmunol Arboviruses, BR-05508020 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Immunopathol & Allergy Post Grad Program, BR-01246000 Sao Paulo - Brazil

• Document type: Review article
• Source: Viruses-Basel; v. 13, n. 10 OCT 2021.
• Web of Science Citations: 0

Abstract

Over the years, viral infections have caused severe illness in humans. Zika Virus (ZIKV) is a flavivirus transmitted by mosquito vectors that leads to notable neurological impairment, whose most dramatic impact is the Congenital ZIKV Syndrome (CZS). ZIKV targets neuronal precursor cells leading to apoptosis and further impairment of neuronal development, causing microcephaly, lissencephaly, ventriculomegaly, and calcifications. Several regulators of biological processes are involved in CZS development, and in this context, microRNAs (miRNAs) seem to have a fundamental role. miRNAs are important regulators of protein translation, as they form the RISC silencing complex and interact with complementary mRNA target sequences to further post-transcriptional repression. In this context, little is known about their participation in the pathogenesis of viral infections. In this review, we discuss how miRNAs could relate to ZIKV and other flavivirus infections.</p> (AU)

• FAPESP's process: 19/13731-0 - MicroRNAs, neurodevelopment and antiviral immune response: how they can be connected?
• Grantee: Carolina Manganeli Polonio
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 17/26170-0 - Neuroimmunology in experimental models of Autoimmune Encephalomyelitis and Congenital Zika Syndrome: physiopathogenesis, susceptibility, cellular therapy, vaccination
• Grantee: Jean Pierre Schatzmann Peron
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/06145-4 - Immunopathogenesis of COVID-19 in experimental models and nasal vaccine anti-SARS-CoV-2
• Grantee: Jean Pierre Schatzmann Peron
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/11828-0 - Evaluation of the microRNAs role in the immunopathogenesis of microcephaly caused by Zika virus in experimental models
• Grantee: Carolina Manganeli Polonio
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/22504-1 - TAM receptors and their ligands Gas6 and Pros1 on the ZIKV Congenital Syndrome in Experimental Models
• Grantee: Jean Pierre Schatzmann Peron
• Support Opportunities: Regular Research Grants