| Full text | |
| Author(s): |
Neves, Jorge Henrique
[1]
;
Rezende-Teixeira, Paula
[1]
;
Palomino, Natalia Bazan
[1]
;
Machado-Santelli, Glaucia Maria
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Ave Prof Lineu Prestes 1524, Sala 307, Sao Paulo, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | OPEN BIOLOGY; v. 11, n. 11 NOV 10 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Gap junctions mediate communication between adjacent cells and are fundamental to the development and homeostasis in multicellular organisms. In invertebrates, gap junctions are formed by transmembrane proteins called innexins. Gap junctions allow the passage of small molecules through an intercellular channel, between a cell and another adjacent cell. The dipteran Rhynchosciara americana has contributed to studying the biology of invertebrates and the study of the interaction and regulation of genes during biological development. Therefore, this paper aimed to study the R. americana innexin-2 by molecular characterization, analysis of the expression profile and cellular localization. The molecular characterization results confirm that the message is from a gap junction protein and analysis of the expression and cellular localization profile shows that innexin-2 can participate in many physiological processes during the development of R. americana. (AU) | |
| FAPESP's process: | 12/03370-0 - Molecular characterization of innexins and their role in the gap junctional communication in Rhynchosciara americana |
| Grantee: | Glaucia Maria Machado Santelli |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 10/04282-2 - GAP junctions in Rhynchosciara americana ovary: Molecular characterization, localization and expression profile of innexin 4 |
| Grantee: | Natalia Bazán Palomino |
| Support Opportunities: | Scholarships in Brazil - Master |