Pro-angiogenic approach for skeletal muscle regeneration

Author(s):Show less -

Floriano, Juliana Ferreira ^{[1, 2]} ; Emanueli, Costanza ^[1] ; Vega, Sofia ^{[2, 3]} ; Pascon Barbosa, Angelica Mercia ^[4] ; de Oliveira, Rafael Guilen ^[2] ; Ferreira Floriano, Emerson Aparecido ^[5] ; de Oliveira Graeff, Carlos Frederico ^[6] ; Abbade, Joelcio Francisco ^[2] ; Herculano, Rondinelli Donizete ^[7] ; Sobrevia, Luis ^{[8, 9, 2, 3, 10]} ; Cunha Rudge, Marilza Vieira ^[2] ; Grp, DIAMATER Study

Affiliation

^[1] Imperial Coll London, Natl Heart & Lung Inst, London - England

^[2] Sao Paulo State Univ UNESP, Botucatu Med Sch, BR-18618687 Botucatu, SP - Brazil

^[3] Pontificia Univ Catolica Chile, Fac Med, Cellular & Mol Physiol Lab CMPL, Sch Med, Dept Obstet, Div Obstet & Gynaecol, POB 114-D, Santiago 8330024 - Chile

^[4] Sao Paulo State Univ UNESP, Sch Philosophy & Sci, BR-17525900 Marilia, SP - Brazil

^[5] Fed Inst Sao Paulo IFSP, BR-18707150 Avare, SP - Brazil

^[6] Sao Paulo State Univ UNESP, Sci Fac, BR-17033360 Bauru, SP - Brazil

^[7] Sao Paulo State Univ UNESP, Fac Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil

^[8] Univ Seville, Fac Pharm, Dept Physiol, E-41012 Seville - Spain

^[9] Univ Queensland, Fac Med & Biomed Sci, Ctr Clin Res UQCCR, Herston, Qld 4029 - Australia

^[10] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, NL-9713 GZ Groningen - Netherlands

• Document type: Journal article
• Source: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS; v. 1866, n. 2 FEB 2022.
• Web of Science Citations: 0

Abstract

The angiogenesis process is a phenomenon in which numerous molecules participate in the stimulation of the new vessels' formation from pre-existing vessels. Angiogenesis is a crucial step in tissue regeneration and recovery of organ and tissue function. Muscle diseases affect millions of people worldwide overcome the ability of skeletal muscle to self-repair. Pro-angiogenic therapies are key in skeletal muscle regeneration where both myogenesis and angiogenesis occur. These therapies have been based on mesenchymal stem cells (MSCs), exo-somes, microRNAs (miRs) and delivery of biological factors. The use of different calls of biomaterials is another approach, including ceramics, composites, and polymers. Natural polymers are use due its bioactivity and biocompatibility in addition to its use as scaffolds and in drug delivery systems. One of these polymers is the natural rubber latex (NRL) which is biocompatible, bioactive, versatile, low-costing, and capable of promoting tissue regeneration and angiogenesis. In this review, the advances in the field of pro-angiogenic therapies are discussed. (AU)

• FAPESP's process: 18/22406-2 - Exosomes in gestational Diabetes Mellitus
• Grantee: Marilza Vieira Cunha Rudge
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/21783-4 - Gestational triad cohort: hyperglycemia, urinary incontinence and clinical, molecular and omic profile of hyperglycemic myopathy in predicting incontinence and muscle dysfunction and translational research with biodevice for muscle regeneration in rats
• Grantee: Juliana Ferreira Floriano
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/01743-5 - The new gestational triad: hyperglycemia, urinary incontinence (UI) and biomolecular profile as a long-term predictor for UI: a prospective cohort study: translational research with biodevice with stem cells for muscle regeneration in diabetic rats
• Grantee: Marilza Vieira Cunha Rudge
• Support Opportunities: Research Projects - Thematic Grants