| Full text | |
| Author(s): |
Total Authors: 3
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| Affiliation: | [1] Univ Lubeck, Ctr Brain Behav & Metab CBBM, Inst Neurobiol, Marie Curie Str, D-23562 Lubeck - Germany
[2] Univ Fed Sao Paulo, UNIFESP, Dept Biochem, Sao Paulo - Brazil
[3] CSIC, Inst Cajal, Madrid - Spain
Total Affiliations: 3
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| Document type: | Review article |
| Source: | Glia; NOV 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Since the early observations made by Santiago Ramon y Cajal more than a century ago till now, astrocytes have gradually gained protagonism as essential partners of neurons in building brain circuits that regulate complex behavior. In mammals, processes such as sleep-wake cycle, locomotor activity, cognition and memory consolidation, homeostatic and hedonic appetite and stress response (among others), are synchronized in 24-h rhythms by the circadian system. In such a way, physiology efficiently anticipates and adapts to daily recurring changes in the environment. The hypothalamic suprachiasmatic nucleus (SCN) is considered the central pacemaker, it has been traditionally described as a nucleus of around 10,000 neurons nearly all GABAergic able to be entrained by light and to convey time information through multiple neuronal and hormonal pathways. Only recently, this neuro-centered view was challenged by breakthrough discoveries implicating astrocytes as essential time-keepers. In the present review, we will describe the current view on the SCN circuit and discuss whether astrocytic functions described in other brain regions and state-of-the-art experimental approaches, could help explaining better those well- and not so well-known features of the central pacemaker. (AU) | |
| FAPESP's process: | 16/19084-8 - Crosstalk among Wnt, SHH and Notch and the efect of Gal3 protein on the regulation of the proliferation of derived-neural stem cells reactive astrocytes |
| Grantee: | Lina Maria Delgado Garcia |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 19/09183-7 - Characterization of astroglial clonal responses in experimental animal models of brain injury |
| Grantee: | Lina Maria Delgado Garcia |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |