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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: A cross-sectional study

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Heubel, Alessandro Domingues [1] ; Viana, Ariane Aparecida [2] ; Linares, Stephanie Nogueira [1] ; do Amaral, Vanessa Teixeira [2] ; Schafauser, Nathany Souza [1] ; Orikassa de Oliveira, Gustavo Yudi [2] ; Ramirez, Paula Camila [3, 4] ; Martinelli, Bruno [5] ; Alexandre, Tiago da Silva [3] ; Borghi-Silva, Audrey [1] ; Ciolac, Emmanuel Gomes [2] ; Mendes, Renata Goncalves [1]
Total Authors: 12
[1] Univ Fed Sao Carlos, Dept Phys Therapy, Cardiopulm Physiotherapy Lab, Sao Carlos, SP - Brazil
[2] Sao Paulo State Univ, Sch Sci, Dept Phys Educ, Exercise & Chron Dis Res Lab, Bauru, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Gerontol, Sao Carlos, SP - Brazil
[4] Univ Ind Santander, Dept Phys Therapy, Santander - Colombia
[5] Sacred Heart Univ Ctr, Dept Phys Therapy, Bauru, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: OBESITY; v. 30, n. 1 NOV 2021.
Web of Science Citations: 1

Objective The aim of this study was to identify determinants of endothelial dysfunction in patients hospitalized with acute COVID-19. Methods A total of 109 hospitalized COVID-19 patients in noncritical status were cross-sectionally studied. Clinical data (age, sex, comorbidities, and medications) and BMI were assessed. Laboratory tests included serum hemoglobin, leukocytes, lymphocytes, platelets, C-reactive protein, ferritin, D-dimer, and creatinine. Physical status was evaluated using a handgrip dynamometer. Endothelial function was assessed noninvasively using the flow-mediated dilation (FMD) method. Results The sample average age was 51 years, 51% of patients were male, and the most frequent comorbidity was obesity (62%). Univariate analysis showed association of lower FMD with higher BMI, hypertension, use of oral antihypertensive, higher blood levels of creatinine, and larger baseline artery diameter. After adjusting for confounders, the multivariate analysis showed BMI (95% CI: -0.26 to -0.11; p < 0.001) as the major factor associated with FMD. Other factors associated with FMD were baseline artery diameter (95% CI: -1.77 to -0.29; p = 0.007) and blood levels of creatinine (95% CI: -1.99 to -0.16; p = 0.022). Conclusions Increased BMI was the major factor associated with endothelial dysfunction in noncritically hospitalized COVID-19 patients. This may explain one of the pathways in which obesity may increase the risk for severe COVID-19. (AU)

FAPESP's process: 15/09259-2 - Acute hemodynamic responses to heated water-based exercise in older hypertensive patients
Grantee:Awassi Yophiwa Ngomane
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 15/26501-1 - Study of limiting factors to physical exercise and adjunct effects to rehabilitation on cardiorespiratory disease: a multicentre approach
Grantee:Audrey Borghi e Silva
Support Opportunities: Research Projects - Thematic Grants