Study of limiting factors to physical exercise and adjunct effects to rehabilitation on cardiorespiratory disease: a multicentre approach

• Grant number: 15/26501-1
• Support Opportunities: Research Projects - Thematic Grants
• Start date: December 01, 2017
• End date: November 30, 2023
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Audrey Borghi Silva
• Grantee: Audrey Borghi Silva
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Pesquisadores principais: Renata Gonçalves Mendes
• Associated researchers: Claudio Ricardo de Oliveira ; Fabíola Paula Galhardo Rizzatti ; Meliza Goi Roscani ; Renata Trimer
• Associated scholarship(s): 23/04073-4 - Assessment of Obstructive Sleep Apnea by type IV polysomnography and the sleep quality questionnaire and its relationship with functional capacity in a patient with Chronic Obstructive Pulmonary Disease, BP.IC; 23/06328-0 - EVALUATION OF MECHANICAL-VENTILATORY, CARDIOCIRCULATORY AND METABOLIC RESPONSES IN DYNAMIC INCREMENTAL EXERCISE TEST LIMITED SYMPTOM - COMPARISON WITH INTERNATIONAL FRIENDS STUDY AND NATIONAL DATA, BP.PD; 23/03834-1 - EVALUATION OF FUNCTIONAL CAPACITY, VARIABILITY AND ON AND OFF KINETICS OF HEART RATE DURING THE SIX-MINUTE WALK TEST IN PATIENTS WITH COPD, BP.IC; + associated scholarships 23/00539-9 - Impact of the coexistence of chronic obstructive pulmonary disease and heart failure and non-ventilating support invasive effect on endothelial function and cardiac autonomic modulation after exacerbation, BP.TT; 22/13556-6 - Does non-invasive ventilatory support have an effect on endothelial function in a patient with decompensated heart failure? A quasi-experimental study., BP.IC; 22/14194-0 - STUDY OF LIMITING FACTORS TO PHYSICAL EXERCISE AND EFFECTS OF RESOURCES ASSOCIATED WITH REHABILITATION IN CHRONIC CARDIORESPIRATORY DISEASES - A MULTICENTRIC APPROACH, BP.TT; 22/09347-2 - Impact of the coexistence of chronic obstructive pulmonary disease and heart failure and of non-invasive ventilatory support on endothelial function and cardiac autonomic modulation in the hospitalization phase after exacerbation, BP.TT; 22/07591-3 - Follow-up study on chronic obstructive pulmonary disease, heart failure and their coexistence: assessment of limiting factors to physical exercise and the acute effects of noninvasive ventilation, BP.TT; 21/11221-4 - Follow-up study on chronic obstructive pulmonary disease, heart failure and their coexistence: assessment of limiting factors to physical exercise and the acute effects of noninvasive ventilation, BP.TT; 21/02784-5 - Study of factors limiting physical exercise and effects of resources associated with rehabilitation in chronic cardiorrespiratory diseases: a multicentric approach, BP.TT; 21/03493-4 - Innovative assessment tool functional and guiding physical exercise prescription in patients with COPD exacerbated: investigation of clinical applicability and vascular and functional benefits, BP.DD; 19/23548-8 - Investigation of phenotype in exacerbated COPD: do the major impact and symptomatology reflect worst heart autonomic modulation?, BP.IC; 19/20419-2 - Development of a cardiopulmonary health record - Friends Study, BP.EP; 19/13068-9 - Validity and reliability of the sleep quality index questionnaire in individuals with chronic obstructive pulmonary disease, BP.IC; 19/12515-1 - Study of limiting factors to physical exercise and effects of resources to rehabilitation on chronic cardiorespiratory diseases: a multicentric approach, BP.TT; 19/09828-8 - Analysis of variability of cardiac frequency during constant load exercise with application of binível in COPD-HF patients, BP.IC; 18/18133-0 - Evaluation of mechanical ventilatory, cardiocirculatory and metabolic responses in dynamic exercise incremental symptom limited trial - FRIENDS Study, BP.PD; 18/03314-0 - Follow-up of cardiorrespiratory changes and its impact on capacity of physical exercise in patients with heart failure and COPD overlap, BP.DD; 18/11989-7 - Study of limiting factors to physical exercise and effects of rehabilitation facilities in chronic cardiorespiratory diseases: a multicentric approach, BP.TT; 18/08198-8 - Investigation of functional capacity and arterial function during exercise in patients with COPD, BP.IC; 18/03233-0 - Study of cardiorespiratory interaction and the supply of peripheral and cerebral oxygen as modulators of exercise capacity during bilevel application in the coexistence of COPD-CHF, BP.DD - associated scholarships

Abstract

This proposal comes up for a thematic project involving 2 subprojects of interdependent research and 15 researchers, 6 associate research, 5 international researchers and 3 national researchers from other institutions. In this theme, we propose as the original study a patient follow-up study with COPD, CHF and its coexistence, assessing the impact on morbidity and disability. Also we will investigate prognostic markers from cardiopulmonary exercise testing, through an international partnership, the Consortium Friends, in the context of these diseases and its coexistence. The mechanistic investigation of the limiting factors to exercise on cardiorespiratory function and diaphragmatic, peripheral muscle oxygenation and brain will be important for the integrated understanding of the systems to chronic cardiorespiratory dysfunction in these patients, constituting an important physiological study. We also propose as unpublished essay, the assessment of functional capacity through simple field tests, but on a prototype developed in our institution as well as its construction, expanding its clinical use. In the research line on the adjunct effects of rehabilitation in chronic cardiorespiratory diseases, we propose as original trial, a randomized study evaluating the effects of non-invasive ventilation in patients with CHF + COPD in the chronic phase as well as during exacerbations in different clinical and cardiovascular outcomes. For this, we gathered groups of notorious researchers know to help us in this great proposal, which will surely bring great impact in the scientific field. (AU)

Scientific publications

(69)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

C.F. FAGUNDES; L. DI THOMMAZO-LUPORINI; C.L. GOULART; D. BRAATZ; A. DITOMASO; A. BORGHI-SILVA. Reference equations of oxygen uptake for the step test in the obese population. Brazilian Journal of Medical and Biological Research, v. 55, 2022-03-21. (18/03233-0, 20/13465-5, 15/26501-1)

LOPES ZANGRANDO, KATIANY THAYS; TRIMER, RENATA; SOARES DE CARVALHO, JR., LUIZ CARLOS; TINOCO AREAS, GUILHERME PEIXOTO; ROSSI CARUSO, FLAVIA CRISTINA; CABIDDU, RAMONA; ROSCANI, MELIZA GOI; GALHARDO RIZZATTI, FABIOLA PAULA; BORGHI-SILVA, AUDREY. Chronic obstructive pulmonary disease severity and its association with obstructive sleep apnea syndrome: impact on cardiac autonomic modulation and functional capacity. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 13, p. 1343-1351, 2018. (15/26501-1)

DA LUZ GOULART, CASSIA; TRIMER, RENATA; GARCIA-ARAUJO, ADRIANA SANCHES; CARUSO, FLAVIA ROSSI; RICCI, PAULA ANGELICA; SANTOS, POLLIANA BATISTA; MENDES, RENATA GONCALVES; BORGHI-SILVA, AUDREY. Validity, intra and inter-reliability of manual evaluation of the respiratory muscle strength in asthmatic patients. PHYSIOTHERAPY RESEARCH INTERNATIONAL, JUN 2020. (18/03233-0, 15/26501-1)

SILVA, REBECA NUNES; GOULART, CASSIA DA LUZ; OLIVEIRA, MURILO REZENDE; TACAO, GUILHERME YASSUYUKI; BACK, GUILHERME DIONIR; SEVERIN, RICHARD; FAGHY, MARK A.; ARENA, ROSS; BORGHI-SILVA, AUDREY. Cardiorespiratory and skeletal muscle damage due to COVID-19: making the urgent case for rehabilitation. EXPERT REVIEW OF RESPIRATORY MEDICINE, MAR 2021. (15/26501-1)

C.L. GOULART; F.R. CARUSO; G.P.T. ARÊAS; P.B. DOS SANTOS; P.F. CAMARGO; L.C.S. DE CARVALHO; M.G. ROSCANI; R.G. MENDES; A. BORGHI-SILVA. Impact of chronic obstructive pulmonary disease on linear and nonlinear dynamics of heart rate variability in patients with heart failure. Brazilian Journal of Medical and Biological Research, v. 54, n. 2, 2020-11-27. (15/26501-1, 18/03233-0)

BORGHI-RICARDO, MATHEUS; SIMOES, RODRIGO POLAQUINI; SANTOS, DANIEL AUGUSTO; ARCHIZA, BRUNO; BORGHI-SILVA, AUDREY. Effects of Aging on Hemodynamic Kinetics in Different Intensities of Dynamic Exercise. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 43, n. 01, p. 61-67, JAN 2022. (15/26501-1, 19/03524-7, 13/06385-1)

MARINHO, R. S.; JURGENSEN, S. P.; ARCURI, J. F.; GOULART, C. L.; DOS SANTOS, P. B.; ROSCANI, M. G.; MENDES, R. G.; DE OLIVEIRA, C. R.; CARUSO, F. R.; BORGHI-SILVA, A.. Reliability and validity of six-minute step test in patients with heart failure. Brazilian Journal of Medical and Biological Research, v. 54, n. 10, 2021. (15/26501-1)

SILVA, REBECA NUNES; GOULART, CASSIA DA LUZ; OLIVEIRA, MURILO REZENDE; TACAO, GUILHERME YASSUYUKI; BACK, GUILHERME DIONIR; SEVERIN, RICHARD; FAGHY, MARK A.; ARENA, ROSS; BORGHI-SILVA, AUDREY. Cardiorespiratory and skeletal muscle damage due to COVID-19: making the urgent case for rehabilitation. EXPERT REVIEW OF RESPIRATORY MEDICINE, v. 15, n. 9, p. 1107-1120, SEP 2 2021. (15/26501-1)

AGNOLETO, ALINE; HEUBEL, ALESSANDRO; KABBACH, ERIKA; BORGHI-SILVA, AUDREY; PHILLIPS, SHANE; DI LORENZO, VALERIA PIRES; ROSCANI, MELIZA; JAENISCH, RODRIGO; MENDES, RENATA. Arterial stiffness, hemodynamic and functional profile at exacerbation and recovery in COPD. European Respiratory Journal, v. 52, p. 2-pg., 2018-09-15. (15/26501-1, 15/12763-4)

MENDES, R. G.; BIAZON, T.; POTT-JUNIOR, H.; CARUSO-BONJORNO, F.; BONJORNO-JUNIOR, J.; LAZZARINI, M.; TACONELLI, M.; SILVA, A. B.. Early Multi-Professional Mobilization on Physical Function, Clinical and Quality Indicators of Intensive Care Delivery in a Low-Resource Setting: An Action on "Rehabilitation 2030" in Brazil. American Journal of Respiratory and Critical Care Medicine, v. 203, n. 9, p. 1-pg., 2021-05-01. (15/26501-1)

MENDES, R. G.; SCHAFAUSER, N.; ROSCANI, M.; OLIVEIRA KAWAKAMI, D.; HEUBEL, A. D.; KABBACH, E. Z.; LEONARDI, N.; CASTELLO-SIMOES, V.; DI LORENZO, V.; SILVA, A. B.. The Underappreciated Connection Between Different Aspects of Muscle and Cardiovascular Function During Exacerbation of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine, v. 205, p. 2-pg., 2022-05-01. (15/12763-4, 15/26501-1)

KAMILA MOHAMMAD KAMAL MANSOUR; CÁSSIA DA LUZ GOULART; LUIZ CARLOS SOARES DE CARVALHO-JUNIOR; RENATA TRIMER; AUDREY BORGHI-SILVA; ANDRÉA LÚCIA GONÇALVES DA SILVA. Pontos de corte da função pulmonar e capacidade funcional determinantes para sarcopenia e dinapenia em pacientes com DPOC. Jornal Brasileiro de Pneumologia, v. 45, n. 6, 2019-10-17. (15/26501-1, 18/03233-0)

LEONARDI, N.; KABBACH, E. Z.; HEUBEL, A. D.; SCHAFAUSER, N. S.; KAWAKAMI, D. M.; CASTELLO-SIMOES, V.; DI LORENZO, V. A. P.; BORGHI-SILVA, A.; MENDES, R.. Who are the COPD patients who have reduced exercise capacity during recovery from hospitalization for acute exacerbation of COPD (AECOPD)? A longitudinal observational study. European Respiratory Journal, v. 60, p. 2-pg., 2022-09-04. (21/03493-4, 15/26501-1, 15/12763-4)

KABBACH, ERIKA ZAVAGLIA; HEUBEL, ALESSANDRO DOMINGUES; DA LUZ GOULART, CASSIA; DI LORENZO, VALERIA AMORIM PIRES; PHILLIPS, SHANE A.; BORGHI-SILVA, AUDREY; MENDES, RENATA GONCALVES. Association of exercise capacity and endothelial function in patients with severe exacerbations of chronic obstructive pulmonary disease. SCIENTIFIC REPORTS, v. 11, n. 1, JAN 11 2021. (15/26501-1, 15/12763-4)

GOULART, CASSIA DA LUZ; SILVA, REBECA NUNES; OLIVEIRA, MURILO REZENDE; GUIZILINI, SOLANGE; ROCCO, ISADORA SALVADOR; MENDEZ, VANESSA MARQUES FERREIRA; BONJORNO, JOSE CARLOS; CARUSO, FLAVIA ROSSI; ARENA, ROSS; BORGHI-SILVA, AUDREY. Lifestyle and rehabilitation during the COVID-19 pandemic: guidance for health professionals and support for exercise and rehabilitation programs. EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, v. 19, n. 11, p. 1385-1396, NOV 2 2021. (15/26501-1, 18/03233-0)

GOULART, CASSIA LUZ; TINOCO AREAS, GUILHERME PEIXOTO; CARUSO, FLAVIA ROSSI; GARCIA ARAUJO, ADRIANA S.; GARCIA DE MOURA, SILVIA CRISTINA; CATAI, APARECIDA MARIA; BELTRAME, THOMAS; DE CARVALHO JUNIOR, LUIZ CARLOS; DOS SANTOS, POLLIANA BATISTA; ROSCANI, MELIZA GOI; et al. Effect of high-intensity exercise on cerebral, respiratory and peripheral muscle oxygenation of HF and COPD-HF patients. HEART & LUNG, v. 50, n. 1, p. 113-120, JAN-FEB 2021. (15/26501-1, 18/03233-0)

BORGHI-SILVA, AUDREY; BACK, GUILHERME DIONIR; DE ARAUJO, ADRIANA S. GARCIA; OLIVEIRA, MURILO REZENDE; GOULART, CASSIA DA LUZ; SILVA, REBECA NUNES; BASSI, DANIELA; MENDES, RENATA GONCALVES; ARENA, ROSS. COVID-19 seen from a syndemic perspective: Impact of unhealthy habits and future perspectives to combat these negative interactions in Latin America. PROGRESS IN CARDIOVASCULAR DISEASES, v. 71, p. 7-pg., 2022-03-01. (18/03233-0, 15/26501-1)

MARIANA BRASIL DA CUNHA MARTINO PEREIRA; VIVIANE CASTELLO-SIMÕES; ALESSANDRO DOMINGUES HEUBEL; ERIKA ZAVAGLIA KABBACH; NATHANY SOUZA SCHAFAUSER; MELIZA GOI ROSCANI; AUDREY BORGHI-SILVA; RENATA GONÇALVES MENDES. Comparação da função e estrutura cardíaca e sua relação com a capacidade de exercício entre pacientes com DPOC estável e exacerbação aguda recente: estudo transversal. Jornal Brasileiro de Pneumologia, v. 48, n. 5, 2022-11-14. (15/26501-1)

LEONARDI, NAIARA TAIS; KAWAKAMI, DEBORA MAYUMI OLIVEIRA; HURST, JOHN R.; CRUZ, JOANA; MENDES, RENATA GONSALVES. Performance-based outcome measures to assess functionality in hospitalised patients with COPD exacerbations: a systematic review of the measurement properties. EUROPEAN RESPIRATORY REVIEW, v. 32, n. 169, p. 17-pg., 2023-09-30. (15/12763-4, 21/03493-4, 15/26501-1)

MENDES, R. G.; HEUBEL, A. D.; KABBACH, E. Z.; SCHAFAUSER, N.; PHILLIPS, S.; PIRES-DI-LORENZO, V.; SILVA, A. B.. Identifying Endothelial Vascular Responders to Noninvasive Ventilation in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine, v. 203, n. 9, p. 1-pg., 2021-05-01. (15/12763-4, 15/26501-1)

GOULART, C. L.; OLIVEIRA, M. R.; RENATA, M. G.; SILVA, A. B.. Prognostic Value of Key Variables from Cardiopulmonary Exercise Testing in Patients with COPD: 42-Month Follow-Up. American Journal of Respiratory and Critical Care Medicine, v. 205, p. 1-pg., 2022-05-01. (18/03233-0, 15/26501-1, 20/13465-5)

LEONARDI, N.; KABBACH, E. Z.; SCHAFAUSER, N. S.; HEUBEL, A. D.; SENTANIN, A. C.; CASTELLO-SIMOES, V.; DI LORENZO, V. A. P.; SILVA, A. B.; MENDES, R. G.. Hospital Rehabilitation Using Elastic Bands Provides Early Improvements and Maintenance of Endothelial Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD): a Randomized Controlled Trial. American Journal of Respiratory and Critical Care Medicine, v. 205, p. 1-pg., 2022-05-01. (15/12763-4, 15/26501-1, 21/03493-4)

BORGHI-SILVA, AUDREY; GARCIA-ARAUJO, ADRIANA S.; WINKERMANN, ELIANE; CARUSO, FLAVIA R.; BASSI-DIBAI, DANIELA; GOULART, CASSIA DA LUZ; DIXIT, SNEHIL; BACK, GUILHERME DIONIR; MENDES, RENATA G.. Exercise-Based Rehabilitation Delivery Models in Comorbid Chronic Pulmonary Disease and Chronic Heart Failure. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 8, p. 9-pg., 2021-10-13. (18/03233-0, 15/26501-1)

BACK, G. D.; OLIVEIRA, M. R.; CAMARGO, P. F.; GOULART, C. L.; OLIVEIRA, C. R.; WENDE, K. W.; BONJORNO JUNIOR, J. C.; ARBEX, R. F.; CARUSO, F. R.; ARENA, R.; et al. Mild-to-moderate COVID-19 impact on the cardiorespiratory fitness in young and middle-aged populations. Brazilian Journal of Medical and Biological Research, v. 55, n. 1, p. 13-pg., 2022-01-01. (20/15726-0, 15/26501-1)

DA LUZ GOULART, CASSIA; TRIMER, RENATA; GARCIA-ARAUJO, ADRIANA SANCHES; CARUSO, FLAVIA ROSSI; RICCI, PAULA ANGELICA; SANTOS, POLLIANA BATISTA; MENDES, RENATA GONCALVES; BORGHI-SILVA, AUDREY. Validity, intra and inter-reliability of manual evaluation of the respiratory muscle strength in asthmatic patients. PHYSIOTHERAPY RESEARCH INTERNATIONAL, v. 25, n. 4, p. 8-pg., 2020-06-09. (18/03233-0, 15/26501-1)

MENDES, R. G.; SCHAFAUSER, N. S.; KABBACH, E. Z.; HEUBEL, A. D.; SGARBOSA, N.; LEONARDI, N.; SILVA, A. B.. Phenotypes Investigation in Exacerbated Chronic Obstructive Pulmonary Disease: Does the Greatest Impact and Symptoms Reflect in Worse Cardiac Autonomic Modulation?. American Journal of Respiratory and Critical Care Medicine, v. 201, p. 1-pg., 2020-01-01. (15/12763-4, 15/26501-1)

CAMARGO, PATRICIA; DI THOMMAZO-LUPORINI, LUCIANA; SEBOLD, RAYANE; GOULART, CASSIA; SANTOS, POLLIANA; MARINHO, RENAN; BORGHI-SILVA, AUDREY. Obstructive Sleep Apnea causes negative impact on parasympathetic modulation of patients with COPD. European Respiratory Journal, v. 56, p. 3-pg., 2020-09-07. (18/00860-3, 15/26501-1)

SILVA, R. N.; GOULART, C. D.; BACK, G. D.; OLIVEIRA, C. R.; SILVA, A. B.. Does Respiratory Muscle Strength Substantially Improve Prognostic Evaluation and Risk Stratification in Moderate-to-Very Severe Chronic Obstructive Pulmonary Disease (COPD)? A 42-Month Follow-up Analysis. American Journal of Respiratory and Critical Care Medicine, v. 207, p. 2-pg., 2023-05-01. (15/26501-1)

CAMARGO, P.; SOARES DE CARVALHO JUNIOR, L.; LUPORINI, L.; AREAS, G.; ZANGRANDO, K.; GOULART, C.; DOS SANTOS, P.; MARINHO, R.; ARBEX, R.; BORGHI-SILVA, A.. Cardiac Autonomic Behavior During Passive Postural Change in Individuals in the Overlapping of Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea Syndrome. American Journal of Respiratory and Critical Care Medicine, v. 199, p. 2-pg., 2019-01-01. (18/00860-3, 15/26501-1)

MARINHO, R.; DOS SANTOS, P. B.; GOULART, C. D. L.; AREAS, G. P. T.; CAMARGO, P. F.; JURGENSEN, S. P.; ROSCANI, M. G.; OLIVEIRA, C. R.; CARUSO, F. R. R.; MANSOUR, K. M.; et al. Six-Minute Step Test Can Be Considered Maximum Effort in COPD Patients?. American Journal of Respiratory and Critical Care Medicine, v. 199, p. 2-pg., 2019-01-01. (18/03314-0, 15/26501-1)

GOULART, C.; SCHWARTZMANN, P. V.; AEREAS, G. P. T.; DOS SANTOS, P. B.; MARINHO, R. S.; MANSOUR, K. M. K.; MENDES, R. G.; DA SILVA, A. L. G.; CARUSO, F. R.; BORGHI-SILVA, A.. Clinical Variables of Cardiopulmonary Exercise Testing: Identifying Relative Cut-Off Scores to Determine Prognostic Values in Chagas-Heart Failure Patients. American Journal of Respiratory and Critical Care Medicine, v. 199, p. 2-pg., 2019-01-01. (18/03233-0, 15/26501-1)

MENDES, R. G.; KABBACH, E. Z.; HEUBEL, A. D.; TOMAZ, C.; SENTANIN, A.; BORGHI-SILVA, A.. Endothelial Function and Functional Capacity at Exacerbation and Early Recovery in Chronic Obstructive Pulmonary Disease (COPD) Patients. American Journal of Respiratory and Critical Care Medicine, v. 199, p. 1-pg., 2019-01-01. (15/12763-4, 15/26501-1)

CARVALHO, LUIZ CARLOS S., JR.; TRIMER, RENATA; AREAS, GUILHERME P. T.; CARUSO, FLAVIA C. R.; ZANGRANDO, KATIANY T. L.; JURGENSEN, SORAIA PILON; BONJORNO, JOSE C., JR.; DE OLIVEIRA, CLAUDIO RICARDO; CABIDDU, RAMONA; MENDES, RENATA G.; et al. COPD assessment test and FEV1: do they predict oxygen uptake in COPD?. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 13, p. 8-pg., 2018-01-01. (15/26501-1)

LOPES ZANGRANDO, KATIANY THAYS; TRIMER, RENATA; SOARES DE CARVALHO, LUIZ CARLOS, JR.; TINOCO AREAS, GUILHERME PEIXOTO; ROSSI CARUSO, FLAVIA CRISTINA; CABIDDU, RAMONA; ROSCANI, MELIZA GOI; GALHARDO RIZZATTI, FABIOLA PAULA; BORGHI-SILVA, AUDREY. Chronic obstructive pulmonary disease severity and its association with obstructive sleep apnea syndrome: impact on cardiac autonomic modulation and functional capacity. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 13, p. 9-pg., 2018-01-01. (15/26501-1)

BORGHI-RICARDO, MATHEUS; SIMOES, RODRIGO POLAQUINI; SANTOS, DANIEL AUGUSTO; ARCHIZA, BRUNO; BORGHI-SILVA, AUDREY. Effects of Aging on Hemodynamic Kinetics in Different Intensities of Dynamic Exercise. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, JUN 2021. (19/03524-7, 13/06385-1, 15/26501-1)

CAMARGO, PATRICIA FARIA; DITOMASO-LUPORINI, LUCIANA; SOARES DE CARVALHO JR, LUIZ CARLOS; GOULART, CASSIA DA LUZ; SEBOLD, RAYANE; DOS SANTOS, POLLIANA BATISTA; ROSCANI, MELIZA GOI; BORGHI-SILVA, AUDREY. Association Between the Predictors of Functional Capacity and Heart Rate Off-Kinetics in Patients with Chronic Obstructive Pulmonary Disease. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 15, p. 1977-1986, 2020. (15/26501-1, 18/00860-3)

CARVALHO, JR., LUIZ CARLOS S.; TRIMER, RENATA; AREAS, GUILHERME P. T.; CARUSO, FLAVIA C. R.; ZANGRANDO, KATIANY T. L.; JURGENSEN, SORAIA PILON; BONJORNO, JR., JOSE C.; DE OLIVEIRA, CLAUDIO RICARDO; CABIDDU, RAMONA; MENDES, RENATA G.; et al. COPD assessment test and FEV1: do they predict oxygen uptake in COPD?. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 13, p. 3149-3156, 2018. (15/26501-1)

DOS SANTOS, POLLIANA B.; SIMOES, RODRIGO P.; GOULART, CASSIA L.; ROSCANI, MELIZA G.; MARINHO, RENAN S.; CAMARGO, PATRICIA FARIA; ARBEX, RENATA F.; CASALE, GUILHERME; OLIVEIRA, CLAUDIO R.; MENDES, RENATA G.; et al. Eccentric Left Ventricular Hypertrophy and Left and Right Cardiac Function in Chronic Heart Failure with or without Coexisting COPD: Impact on Exercise Performance. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 16, p. 203-214, 2021. (15/26501-1, 18/03314-0)

G.D. BACK; M.R. OLIVEIRA; P.F. CAMARGO; C.L. GOULART; C.R. OLIVEIRA; K.W. WENDE; J.C. BONJORNO JUNIOR; R.F. ARBEX; F.R. CARUSO; R. ARENA; et al. Mild-to-moderate COVID-19 impact on the cardiorespiratory fitness in young and middle-aged populations. Brazilian Journal of Medical and Biological Research, v. 55, 2022-07-13. (20/15726-0, 15/26501-1)

BORGHI-SILVA, AUDREY; GOULART, CASSIA DA LUZ; CARRASCOSA, CLAUDIA R.; OLIVEIRA, CRISTINO CARNEIRO; BERTON, DANILO C.; DE ALMEIDA, DIRCEU RODRIGUES; NERY, LUIZ EDUARDO; ARENA, ROSS; NEDER, J. ALBERTO. Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction. FRONTIERS IN PHYSIOLOGY, v. 12, JUN 21 2021. (15/26501-1, 18/03233-0)

KABBACH, E. Z.; HEUBEL, A. D.; SCHAFAUSER, N. S.; GOULART, C. L.; BORGHI-SILVA, A.; MENDES, R. G.. Walking Performance Accounts for Endothelial Function in Severe Exacerbation of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine, v. 203, n. 9, p. 1-pg., 2021-05-01. (15/12763-4, 15/26501-1)

HEUBEL, ALESSANDRO D.; KABBACH, ERIKA Z.; LEONARDI, NAIARA T.; SCHAFAUSER, NATHANY S.; KAWAKAMIA, DEBORA M. O.; SENTANIN, ANNA CLAUDIA; DI LORENZOA, VALERIA A. PIRES; SILVA, AUDREY BORGHI; HURST, JOHN R.; MENDES, RENATA G.. Respiratory and peripheral muscle strength influence recovery of exercise capacity after severe exacerbation of COPD? An observational prospective cohort study. HEART & LUNG, v. 58, p. 7-pg., 2023-03-01. (15/26501-1, 15/12763-4)

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