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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pulmonary function and functional capacity cut-off point to establish sarcopenia and dynapenia in patients with COPD

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Author(s):
Kamila Mohammad Kamal Mansour [1] ; Cássia da Luz Goulart [2] ; Luiz Carlos Soares de Carvalho-Junior [3] ; Renata Trimer [4] ; Audrey Borghi-Silva [5] ; Andréa Lúcia Gonçalves da Silva
Total Authors: 6
Affiliation:
[1] Universidade de Santa Cruz do Sul - Brasil
[2] Universidade Federal de São Carlos. Laboratório de Fisioterapia Cardiopulmonar - Brasil
[3] Universidade Federal de São Carlos. Laboratório de Fisioterapia Cardiopulmonar - Brasil
[4] Universidade de Santa Cruz do Sul. Departamento de Educação Física e Saúde - Brasil
[5] Universidade Federal de São Carlos. Laboratório de Fisioterapia Cardiopulmonar - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Jornal Brasileiro de Pneumologia; v. 45, n. 6 2019-10-17.
Abstract

ABSTRACT Objective To establish a cut-off point for clinical and functional variables to determinate sarcopenia and dynapenia in COPD patients, and to analyze the impact of skeletal muscle dysfunction (SMD) on these variables. Methods Cross-sectional study, screened COPD patients for sarcopenia or dynapenia through low muscle mass and hand grip strength (HGS). Clinical variables: pulmonary function, respiratory muscle strength and functional capacity (FC). The precision of the variables in determining points of predictive cut-off for sarcopenia or dynapenia were performed using the Receiver Operating Characteristic curve and two-way analysis of variance. Results 20 COPD patients stratified for sarcopenia (n = 11) and dynapenia (n = 07). Sarcopenia group presented lower lean mass and lower maximal inspiratory pressure (MIP), decreased HGS, reduced FC (p<0.050). Dynapenia group presented reduced MIP, lower HGS and walked a shorter distance at Incremental shuttle walk test (ISWT) (p<0.050). We found cut-off points of forced expiratory volume in one second (FEV1), MIP and maximal expiratory pressure (MEP) and ISWT. It is possible to identify sarcopenia or dynapenia in these patients. We found the coexistence of the conditions (SMD effect) in COPD – reduction in the distance in the ISWT (p = 0.002) and %ISWT (p = 0.017). Conclusion In moderate to very severe COPD patients the sarcopenia could be predicted by FEV1 (%predicted) < 52, MIP < 73 cmH2O, MEP < 126 cmH2O and distance traveled of < 295 m in ISWT. Whereas dynapenia could be predicted by FEV1 < 40%, MIP < 71 cmH2O, MEP < 110 cmH2O and distance of < 230 m traveled in ISWT. (AU)

FAPESP's process: 18/03233-0 - Study of cardiorespiratory interaction and the supply of peripheral and cerebral oxygen as modulators of exercise capacity during bilevel application in the coexistence of COPD-CHF
Grantee:Cássia da Luz Goulart
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 15/26501-1 - Study of limiting factors to physical exercise and adjunct effects to rehabilitation on cardiorespiratory disease: a multicentre approach
Grantee:Audrey Borghi e Silva
Support Opportunities: Research Projects - Thematic Grants