Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease

Author(s):Show less -

Castello-Simoes, Viviane ^[1] ; Kabbach, Erika Zavaglia ^[1] ; Schafauser, Nathany Souza ^[1] ; Camargo, Patricia Faria ^[1] ; Simoes, Rodrigo Polaquini ^{[1, 2]} ; Heubel, Alessandro Domingues ^[1] ; Alqahtani, Jaber Saud ^{[3, 4]} ; da Cunha Martino Pereira, Mariana Brasil ^[1] ; Sgarbosa, Nicole Marques ^[1] ; Borghi-Silva, Audrey ^[1] ; Mendes, Renata Goncalves ^[1]

Affiliation

^[1] Fed Univ Sao Carlos UFSCar, Dept Physiotherapy, Cardiopulm Physiotherapy Lab, Rodovia Washington Luis, KM 235, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Alfenas, UNIFAL, Postgrad Program Rehabil Sci, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG - Brazil

^[3] UCL, UCL Resp, Rowland Hill St, London NW3 2PF - England

^[4] Prince Sultan Mil Coll Hlth Sci, Dept Resp Care, Dammam 34313 - Saudi Arabia

• Document type: Journal article
• Source: RESPIRATORY MEDICINE; v. 185, AUG-SEP 2021.
• Web of Science Citations: 0

Abstract

Purpose: Impairment of cardiac autonomic integrity is common in chronic obstructive pulmonary disease (COPD) patients. The influence of the interaction between clinical and severity status on brain-heart autonomic axis (BHAA) is not well known. We aimed to investigate the BHAA function across different clinical status and severity of COPD. Methods: Cross-sectional study involving 77 COPD patients allocated into four groups according to clinical status {[}acute exacerbation (GAE) or stable (GST)] and severity {[}less (-) or more (+)]: 1) GAE-, n = 13; 2) GAE+, n = 20; 3) GST-, n = 23; and 4) GST+, n = 21. Heart rate variability (HRV) at rest and heart rate recovery (HRR) after 6-min walk test were markers of BHAA. Mean R-R, STDRR, RMSSD, RRtri, HF, LF, SD1, SD2, ApEn and SampEn were the HRV indexes and, HRR was obtained as: HR at 1st min of recovery minus peak HR. Results: A main effect of clinical status (p < 0.001) was found to vagal modulation in GAE-vs. GST- (RMSSD: 25.0 +/- 14.8 vs. 12.6 +/- 5.5 ms; SD1: 18.0 +/- 10.6 vs. 8.9 +/- 3.9 ms) and to GAE + vs. GST+ (RMSSD: 26.4 +/- 15.2 vs. 15.4 +/- 6.3 ms; SD1: 18.3 +/- 11.2 vs. 10.9 +/- 4.5 ms). An effect of clinical status (p = 0.032) and severity (p = 0.030) were found to HF (vagal) in GAE + compared to GAE- and GST+ (264.7 +/- 239.0 vs. 134.7 +/- 169.7 and 135.8 +/- 139.7 ms2). Lower HRR was found in GAE-compared to GST- (8.0 +/- 2.4 vs. 19.6 +/- 2.4 bpm), p = 0.002. Conclusion: In COPD patients, clinical status (AECOPD or stable) was more dominant than the severity on BHAA function. A more pronounced parasympathetic modulation was found in AECOPD patients with a lower HRR to exercise. (AU)

• FAPESP's process: 15/26501-1 - Study of limiting factors to physical exercise and adjunct effects to rehabilitation on cardiorespiratory disease: a multicentre approach
• Grantee: Audrey Borghi e Silva
• Support Opportunities: Research Projects - Thematic Grants