Advanced search
Start date
Betweenand

Evaluation of cardiac autonomic modulation and functional capacity in the overlap of Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea Syndrome: a follow-up study

Grant number: 18/00860-3
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): May 01, 2018
Effective date (End): February 28, 2021
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Audrey Borghi e Silva
Grantee:Patrícia Faria Camargo
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a systemic and pulmonary disease that, in association with other diseases, such as Obstructive Sleep Apnea Syndrome (OSAS), may cause greater impairment of functional performance and quality of life. However, it is little known about the coexistence of COPD and OSAS and its impact on the autonomic cardiovascular system and functional impairment in the follow-up over a year. Objectives: To evaluate and determine the impact of OSAS overlapping on COPD, following a year of follow - up, in cardiac autonomic behavior during active and passive postural changes, respiratory sinus arrhythmia maneuver and exercise, as well as functional capacity. Methods: in the first stage, volunteers aged 50 and over will perform a clinical evaluation, pulmonary function tests, echocardiography and sleep home examination in order to be allocated to COPD or COPD + OSAS groups. In the second stage, they will respond to questionnaires and perform an assessment of body composition through bioimpedance and, in the third stage, will pass through the evaluation of autonomic behavior through Heart Rate Variability (HRV) at rest during passive and postural changes active, in the respiratory sinus arrhythmia maneuver, and during the six-minute walk test. In this last test will also be evaluated the functional capacity of the volunteer by means of distance traveled. After a period of one year, in the fourth stage, these patients will be reassessed regarding the aspect of HRV (rest, passive postural change, respiratory sinus arrhythmia maneuver and exercise) and functional capacity. Expected results: It is expected that cardiac and functional autonomic alterations are more impaired in the COPD group with OSAS overlapping in relation to the isolated COPD group, both at rest and during exercise, and that there is a more pronounced functional and autonomic impairment according to progression and severity of diseases. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMARGO, PATRICIA FARIA; DITOMASO-LUPORINI, LUCIANA; SOARES DE CARVALHO JR, LUIZ CARLOS; GOULART, CASSIA DA LUZ; SEBOLD, RAYANE; DOS SANTOS, POLLIANA BATISTA; ROSCANI, MELIZA GOI; BORGHI-SILVA, AUDREY. Association Between the Predictors of Functional Capacity and Heart Rate Off-Kinetics in Patients with Chronic Obstructive Pulmonary Disease. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 15, p. 1977-1986, . (15/26501-1, 18/00860-3)
HEUBEL, ALESSANDRO DOMINGUES; ROSCANI, MELIZA GOI; KABBACH, ERIKA ZAVAGLIA; AGNOLETO, ALINE GALVAO; CAMARGO, PATRICIA FARIA; DOS SANTOS, POLLIANA BATISTA; BORGHI-SILVA, AUDREY; MENDES, RENATA GONCALVES. Left Ventricular Geometry in COPD Patients ARE THERE ASSOCIATIONS WITH AIRFLOW LIMITATION, FUNCTIONAL CAPACITY, AND GRIP STRENGTH?. Journal of Cardiopulmonary Rehabilitation and Prevention, v. 40, n. 5, p. 4-pg., . (15/12763-4, 18/00860-3, 18/03314-0, 15/26501-1)
CAMARGO, PATRICIA FARIA; DITOMASO-LUPORINI, LUCIANA; DE CARVALHO JR, LUIZ CARLOS SOARES; COULART, CASSIA DA LUZ; SANTOS, POLLIANA BATISTA DOS; SEBOLD, RAYANE; ROSCANI, MELIZA GOI; MENDES, RENATA GONCALVES; BORGHI-SILVA, AUDREY. Obstructive sleep apnea reduces functional capacity and impairs cardiac autonomic modulation during submaximal exercise in patients with chronic obstructive pulmonary disease: A follow-up study. HEART & LUNG, v. 57, p. 8-pg., . (18/00860-3, 15/26501-1)
CAMARGO, PATRICIA FARIA; DITOMASO-LUPORINI, LUCIANA; SOARES DE CARVALHO JR, LUIZ CARLOS; GOULART, CASSIA DA LUZ; SEBOLD, RAYANE; DOS SANTOS, POLLIANA BATISTA; ROSCANI, MELIZA GOI; BORGHI-SILVA, AUDREY. Association Between the Predictors of Functional Capacity and Heart Rate Off-Kinetics in Patients with Chronic Obstructive Pulmonary Disease. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 15, p. 10-pg., . (18/00860-3, 15/26501-1)
CAMARGO, P.; SOARES DE CARVALHO JUNIOR, L.; LUPORINI, L.; AREAS, G.; ZANGRANDO, K.; GOULART, C.; DOS SANTOS, P.; MARINHO, R.; ARBEX, R.; BORGHI-SILVA, A.. Cardiac Autonomic Behavior During Passive Postural Change in Individuals in the Overlapping of Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea Syndrome. American Journal of Respiratory and Critical Care Medicine, v. 199, p. 2-pg., . (18/00860-3, 15/26501-1)
CAMARGO, PATRICIA; DI THOMMAZO-LUPORINI, LUCIANA; SEBOLD, RAYANE; GOULART, CASSIA; SANTOS, POLLIANA; MARINHO, RENAN; BORGHI-SILVA, AUDREY. Obstructive Sleep Apnea causes negative impact on parasympathetic modulation of patients with COPD. European Respiratory Journal, v. 56, p. 3-pg., . (18/00860-3, 15/26501-1)

Please report errors in scientific publications list using this form.