Colistin-resistant Enterobacter kobei carrying mcr-9.1 and bla(CTX-M-15) infecting a critically endangered franciscana dolphin (Pontoporia blainvillei), Brazil

Author(s)

Fuentes-Castillo, Danny ^{[1, 2]} ; Sellera, Fabio P. ^{[3, 2]} ; Goldberg, Daphne W. ^[4] ; Fontana, Herrison ^{[5, 2]} ; Esposito, Fernanda ^{[5, 2]} ; Cardoso, Brenda ^{[6, 2]} ; Ikeda, Joana ^[7] ; Kyllar, Anneliese ^{[7, 8]} ; Catao-Dias, Jose L. ^[1] ; Lincopan, Nilton ^{[6, 5, 2]}

Affiliation

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Sao Paulo - Brazil

^[2] One Hlth Brazilian Resistance Project OneBR, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Internal Med, Sao Paulo - Brazil

^[4] Econservat Santos Basin Beach Monitoring Project, Rio De Janeiro - Brazil

^[5] Univ Sao Paulo, Sch Pharm, Dept Clin Anal, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Dept Microbiol, Inst Ciencias Biomed, Sao Paulo - Brazil

^[7] Univ Estado Rio De Janeiro, Fac Oceanog, Lab Aquat Mammals & Bioindicators Profa Izabel MG, Rio De Janeiro - Brazil

^[8] CTA, Santos Basin Beach Monitoring Project, Rio De Janeiro - Brazil

• Document type: Journal article
• Source: TRANSBOUNDARY AND EMERGING DISEASES; v. 68, n. 6, p. 3048-3054, NOV 2021.
• Web of Science Citations: 5

Abstract

The emergence of mobile mcr genes mediating resistance to colistin is a critical public health issue that has hindered the treatment of serious infections caused by multidrug-resistant pathogens in humans and other animals. We report the emergence of the mcr-9.1 gene in a polymyxin-resistant extended-spectrum beta-lactamase (ESBL)-producing Enterobacter kobei infecting a free-living franciscana dolphin (Pontoporia blainvillei), threatened with extinction in South America. Genomic analysis confirmed the presence of genes conferring resistance to clinically relevant beta-lactam {[}bla(CTX-M-15), bla(ACT-9), bla(OXA-1) and bla(TEM-1B)], aminoglycoside {[}aac(3)-IIa, aadA1, aph(3'')-Ib and aph(6)-Id], trimethoprim {[}dfrA14], tetracycline {[}tetA], quinolone {[}aac(6')-Ib-cr and qnrB1], fosfomycin {[}fosA], sulphonamide {[}sul2] and phenicol {[}catA1 and catB3] antibiotics. The identification of mcr-9.1 in a CTX-M-15-producing pathogen infecting a critically endangered animal is of serious concern, which should be interpreted as a sign of further spread of critical priority pathogens and their resistance genes in threatened ecosystems. (AU)

• FAPESP's process: 19/15578-4 - Virulome and pathogenicity of carbapenem- and polymyxin-resistant priority pathogens
• Grantee: Fernanda Ribeiro dos Santos Esposito
• Support Opportunities: Scholarships in Brazil - Doctorate