| Full text | |
| Author(s): |
Fuentes-Castillo, Danny
[1, 2]
;
Sellera, Fabio P.
[3, 2]
;
Goldberg, Daphne W.
[4]
;
Fontana, Herrison
[5, 2]
;
Esposito, Fernanda
[5, 2]
;
Cardoso, Brenda
[6, 2]
;
Ikeda, Joana
[7]
;
Kyllar, Anneliese
[7, 8]
;
Catao-Dias, Jose L.
[1]
;
Lincopan, Nilton
[6, 5, 2]
Total Authors: 10
|
| Affiliation: | [1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Sao Paulo - Brazil
[2] One Hlth Brazilian Resistance Project OneBR, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Internal Med, Sao Paulo - Brazil
[4] Econservat Santos Basin Beach Monitoring Project, Rio De Janeiro - Brazil
[5] Univ Sao Paulo, Sch Pharm, Dept Clin Anal, Sao Paulo - Brazil
[6] Univ Sao Paulo, Dept Microbiol, Inst Ciencias Biomed, Sao Paulo - Brazil
[7] Univ Estado Rio De Janeiro, Fac Oceanog, Lab Aquat Mammals & Bioindicators Profa Izabel MG, Rio De Janeiro - Brazil
[8] CTA, Santos Basin Beach Monitoring Project, Rio De Janeiro - Brazil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | TRANSBOUNDARY AND EMERGING DISEASES; v. 68, n. 6, p. 3048-3054, NOV 2021. |
| Web of Science Citations: | 5 |
| Abstract | |
The emergence of mobile mcr genes mediating resistance to colistin is a critical public health issue that has hindered the treatment of serious infections caused by multidrug-resistant pathogens in humans and other animals. We report the emergence of the mcr-9.1 gene in a polymyxin-resistant extended-spectrum beta-lactamase (ESBL)-producing Enterobacter kobei infecting a free-living franciscana dolphin (Pontoporia blainvillei), threatened with extinction in South America. Genomic analysis confirmed the presence of genes conferring resistance to clinically relevant beta-lactam {[}bla(CTX-M-15), bla(ACT-9), bla(OXA-1) and bla(TEM-1B)], aminoglycoside {[}aac(3)-IIa, aadA1, aph(3'')-Ib and aph(6)-Id], trimethoprim {[}dfrA14], tetracycline {[}tetA], quinolone {[}aac(6')-Ib-cr and qnrB1], fosfomycin {[}fosA], sulphonamide {[}sul2] and phenicol {[}catA1 and catB3] antibiotics. The identification of mcr-9.1 in a CTX-M-15-producing pathogen infecting a critically endangered animal is of serious concern, which should be interpreted as a sign of further spread of critical priority pathogens and their resistance genes in threatened ecosystems. (AU) | |
| FAPESP's process: | 19/15578-4 - Virulome and pathogenicity of carbapenem- and polymyxin-resistant priority pathogens |
| Grantee: | Fernanda Ribeiro dos Santos Esposito |
| Support Opportunities: | Scholarships in Brazil - Doctorate |