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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anatomical atlas of the upper part of the human head for electroencephalography and bioimpedance applications

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Moura, Fernando S. [1, 2] ; Beraldo, Roberto G. [1] ; Ferreira, Leonardo A. [1] ; Siltanen, Samuli [2]
Total Authors: 4
[1] Fed Univ ABC Sao Bernardo do Campo, Engn Modelling & Appl Social Sci Ctr, Sao Paulo - Brazil
[2] Univ Helsinki, Dept Math & Stat, Helsinki - Finland
Total Affiliations: 2
Document type: Journal article
Source: Physiological Measurement; v. 42, n. 10 OCT 1 2021.
Web of Science Citations: 0

Objective. The objective of this work is to develop a 4D (3D+T) statistical anatomical atlas of the electrical properties of the upper part of the human head for cerebral electrophysiology and bioimpedance applications. Approach. The atlas was constructed based on 3D magnetic resonance images (MRI) of 107 human individuals and comprises the electrical properties of the main internal structures and can be adjusted for specific electrical frequencies. T1w+T2w MRI images were used to segment the main structures of the head while angiography MRI was used to segment the main arteries. The proposed atlas also comprises a time-varying model of arterial brain circulation, based on the solution of the Navier-Stokes equation in the main arteries and their vascular territories. Main results. High-resolution, multi-frequency and time-varying anatomical atlases of resistivity, conductivity and relative permittivity were created and evaluated using a forward problem solver for EIT. The atlas was successfully used to simulate electrical impedance tomography measurements indicating the necessity of signal-to-noise between 100 and 125 dB to identify vascular changes due to the cardiac cycle, corroborating previous studies. The source code of the atlas and solver are freely available to download. Significance. Volume conductor problems in cerebral electrophysiology and bioimpedance do not have analytical solutions for nontrivial geometries and require a 3D model of the head and its electrical properties for solving the associated PDEs numerically. Ideally, the model should be made with patient-specific information. In clinical practice, this is not always the case and an average head model is often used. Also, the electrical properties of the tissues might not be completely known due to natural variability. Anatomical atlases are important tools for in silico studies on cerebral circulation and electrophysiology that require statistically consistent data, e.g. machine learning, sensitivity analyses, and as a benchmark to test inverse problem solvers. (AU)

FAPESP's process: 17/18378-0 - Encephalic hemodynamic monitoring using electrical impedance tomography
Grantee:Roberto Gutierrez Beraldo
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 19/09154-7 - Construction of dynamic models of the cerebral circulation for electrical impedance tomography applied in the classification and monitoring of cerebrovascular accidents
Grantee:Fernando Silva de Moura
Support Opportunities: Scholarships abroad - Research