| Full text | |
| Author(s): Show less - |
Castelli, Erick C.
[1, 2]
;
de Almeida, Bibiana S.
[3, 4]
;
Muniz, Yara C. N.
[5]
;
Silva, Nayane S. B.
[2]
;
Passos, Marilia R. S.
[2]
;
Souza, Andreia S.
[2]
;
Page, Abigail E.
[6]
;
Dyble, Mark
[7]
;
Smith, Daniel
[8]
;
Aguileta, Gabriela
[9]
;
Bertranpetit, Jaume
[9]
;
Migliano, Andrea B.
[10]
;
Duarte, Yeda A. O.
[11, 12]
;
Scliar, Marilia O.
[13]
;
Wang, Jaqueline
[13]
;
Passos-Bueno, Maria Rita
[14, 13]
;
Naslavsky, Michel S.
[15, 14, 13]
;
Zatz, Mayana
[14, 13]
;
Mendes-Junior, Celso Teixeira
[16]
;
Donadi, Eduardo A.
[3]
Total Authors: 20
|
| Affiliation: Show less - | [1] Sao Paulo State Univ, UNESP, Dept Pathol, Sch Med, Botucatu, SP - Brazil
[2] Sao Paulo State Univ, UNESP, Mol Genet & Bioinformat Lab, Expt Res Unit, Sch Med, Botucatu, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med, Div Clin Immunol, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Fed Santa Catarina UFSC, Ctr Ciencias Biol, Lab Multiusuario Estudos Biol, Florianopolis, SC - Brazil
[5] Univ Fed Santa Catarina UFSC, Ctr Ciencias Biol, Dept Biol Celular Embriol & Genet, Florianopolis, SC - Brazil
[6] London Sch Hyg & Trop Med, Dept Populat Hlth, London - England
[7] Univ Coll London UCL, Dept Anthropol, London - England
[8] Univ Bristol, Bristol Med Sch PHS, Bristol, Avon - England
[9] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona - Spain
[10] Univ Zurich, Dept Anthropol, Zurich - Switzerland
[11] Univ Sao Paulo, Escola Enfermagem, Sao Paulo, SP - Brazil
[12] Univ Sao Paulo, Fac Saude Publ, Sao Paulo, SP - Brazil
[13] Univ Sao Paulo, Human Genome & Stem Cell Res Ctr, Biosci Inst, Sao Paulo, SP - Brazil
[14] Univ Sao Paulo, Biosci Inst, Dept Genet & Evolutionary Biol, Sao Paulo, SP - Brazil
[15] Hosp Israelita Albert Einstein, Sao Paulo, SP - Brazil
[16] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 16
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 11, n. 1 NOV 29 2021. |
| Web of Science Citations: | 1 |
| Abstract | |
HLA-G is a promiscuous immune checkpoint molecule. The HLA-G gene presents substantial nucleotide variability in its regulatory regions. However, it encodes a limited number of proteins compared to classical HLA class I genes. We characterized the HLA-G genetic variability in 4640 individuals from 88 different population samples across the globe by using a state-of-the-art method to characterize polymorphisms and haplotypes from high-coverage next-generation sequencing data. We also provide insights regarding the HLA-G genetic diversity and a resource for future studies evaluating HLA-G polymorphisms in different populations and association studies. Despite the great haplotype variability, we demonstrated that: (1) most of the HLA-G polymorphisms are in introns and regulatory sequences, and these are the sites with evidence of balancing selection, (2) linkage disequilibrium is high throughout the gene, extending up to HLA-A, (3) there are few proteins frequently observed in worldwide populations, with lack of variation in residues associated with major HLA-G biological properties (dimer formation, interaction with leukocyte receptors). These observations corroborate the role of HLA-G as an immune checkpoint molecule rather than as an antigen-presenting molecule. Understanding HLA-G variability across populations is relevant for disease association and functional studies. (AU) | |
| FAPESP's process: | 17/19223-0 - KIR2DL4, KIR3DL2, KIR3DL3, LILRB1 (ILT2) and LILRB2 (ILT4) variability and haplotypes in a Brazilian population sample from the São Paulo state |
| Grantee: | Erick da Cruz Castelli |
| Support Opportunities: | Regular Research Grants |