The ENIGMA-Epilepsy working group: Mapping disease from large data sets

Author(s):Show less -

Sisodiya, Sanjay M. ^{[1, 2]} ; Whelan, Christopher D. ^[3] ; Hatton, Sean N. ^[4] ; Huynh, Khoa ^[4] ; Altmann, Andre ^[5] ; Ryten, Mina ^[6] ; Vezzani, Annamaria ^[7] ; Caligiuri, Maria Eugenia ^[8] ; Labate, Angelo ^{[9, 8]} ; Gambardella, Antonio ^{[9, 8]} ; Ives-Deliperi, Victoria ^[10] ; Meletti, Stefano ^{[11, 12]} ; Munsell, Brent C. ^{[13, 14]} ; Bonilha, Leonardo ^[15] ; Tondelli, Manuela ^[12] ; Rebsamen, Michael ^[16] ; Rummel, Christian ^[16] ; Vaudano, Anna Elisabetta ^{[11, 12]} ; Wiest, Roland ^[16] ; Balachandra, Akshara R. ^{[17, 4]} ; Bargallo, Nuria ^{[18, 19]} ; Bartolini, Emanuele ^[20] ; Bernasconi, Andrea ^[21] ; Bernasconi, Neda ^[21] ; Bernhardt, Boris ^[22] ; Caldairou, Benoit ^[21] ; Carr, Sarah J. A. ^[23] ; Cavalleri, Gianpiero L. ^{[24, 25]} ; Cendes, Fernando ^{[26, 27]} ; Concha, Luis ^[28] ; Desmond, Patricia M. ^[29] ; Domin, Martin ^[30] ; Duncan, John S. ^{[1, 2]} ; Focke, Niels K. ^[31] ; Guerrini, Renzo ^[32] ; Hamandi, Khalid ^{[33, 34]} ; Jackson, Graeme D. ^{[35, 36]} ; Jahanshad, Neda ^[37] ; Kalviainen, Reetta ^{[38, 39]} ; Keller, Simon S. ^{[40, 41]} ; Kochunov, Peter ^[42] ; Kowalczyk, Magdalena A. ^[35] ; Kreilkamp, Barbara A. K. ^{[40, 41]} ; Kwan, Patrick ^[43] ; Lariviere, Sara ^[22] ; Lenge, Matteo ^{[32, 44]} ; Lopez, Seymour M. ^[5] ; Martin, Pascal ^[45] ; Mascalchi, Mario ^[46] ; Moreira, Jose C. V. ^{[26, 27]} ; Morita-Sherman, Marcia E. ^{[26, 47, 27]} ; Pardoe, Heath R. ^[48] ; Pariente, Jose C. ^[18] ; Raviteja, Kotikalapudi ^{[45, 49, 50]} ; Rocha, Cristiane S. ^{[26, 27]} ; Rodriguez-Cruces, Raul ^{[28, 51]} ; Seeck, Margitta ^[52] ; Semmelroch, Mira K. H. G. ^{[35, 53]} ; Sinclair, Benjamin ^{[54, 55]} ; Soltanian-Zadeh, Hamid ^{[56, 57]} ; Stein, Dan J. ^{[58, 59]} ; Striano, Pasquale ^{[60, 61]} ; Taylor, Peter N. ^[62] ; Thomas, Rhys H. ^[63] ; Thomopoulos, Sophia I. ^[37] ; Velakoulis, Dennis ^{[64, 65]} ; Vivash, Lucy ^{[55, 66]} ; Weber, Bernd ^[67] ; Yasuda, Clarissa Lin ^{[26, 27]} ; Zhang, Junsong ^[68] ; Thompson, Paul M. ^[37] ; McDonald, Carrie R. ^[69]

Affiliation:Show less -

^[1] Chalfont Ctr Epilepsy, Gerrards Cross, Bucks - England

^[2] UCL Queen Sq Inst Neurol, Dept Clin & Expt Epilepsy, London WC1N 3BG - England

^[3] Royal Coll Surgeons Ireland, Dept Mol & Cellular Therapeut, Dublin - Ireland

^[4] Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 - USA

^[5] UCL, Dept Med Phys & Biomed Engn, Ctr Med Image Comp, London - England

^[6] UCL Queen Sq Inst Neurol, London - England

^[7] IRCCS, Ist Ric Farmacol Mario Negri, Dept Neurosci, Milan - Italy

^[8] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Neurosci Res Ctr, Catanzaro - Italy

^[9] Magna Graecia Univ Catanzaro, Inst Neurol, Catanzaro - Italy

^[10] Univ Cape Town, Inst Neurosci, Cape Town - South Africa

^[11] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Modena - Italy

^[12] AOU Modena, OCB Hosp, Neurol Unit, Modena - Italy

^[13] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 - USA

^[14] Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27515 - USA

^[15] Med Univ South Carolina, Dept Neurol, Charleston, SC 29425 - USA

^[16] Univ Bern, Bern Univ Hosp, Univ Inst Diagnost & Intervent Neuroradiol, Support Ctr Adv Neuroimaging, Inselspital, Bern - Switzerland

^[17] Boston Univ, Sch Med, Boston, MA 02118 - USA

^[18] Univ Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Magnet Resonance Image Core Facil, Barcelona - Spain

^[19] Hosp Clin Barcelona, Ctr Image Diag, Dept Radiol, Barcelona - Spain

^[20] Nuovo Osped Santo Stefano, USL Ctr Toscana, Neurol Unit, Prato - Italy

^[21] McGill Univ, Montreal Neurol Inst, Neuroimaging Epilepsy Lab, Montreal, PQ - Canada

^[22] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ - Canada

^[23] Neurosci Inst Psychiat Psychol & Neurosci, London - England

^[24] Royal Coll Surgeons Ireland, Sch Pharm & Biomol Sci, Dublin - Ireland

^[25] FutureNeuro SFI Res Ctr, Dublin - Ireland

^[26] Univ Estadual Campinas, UNICAMP, Dept Neurol, Campinas, SP - Brazil

^[27] Univ Estadual Campinas, UNICAMP, Neuroimaging Lab, Campinas, SP - Brazil

^[28] Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro - Mexico

^[29] Univ Melbourne, Royal Melbourne Hosp, Dept Radiol, Melbourne, Vic - Australia

^[30] Univ Med Greifswald, Dept Diagnost Radiol & Neuroradiol, Funct Imaging Unit, Greifswald - Germany

^[31] Univ Med Gottingen, Clin Neurophysiol, Gottingen - Germany

^[32] Univ Florence, Childrens Hosp A Meyer, Pediat Neurol Neurogenet & Neurobiol Unit & Labs, Florence - Italy

^[33] Univ Hosp Wales, Dept Neurol, Wales Epilepsy Unit, Cardiff - Wales

^[34] Cardiff Univ, Brain Res Imaging Ctr, Sch Psychol, Cardiff - Wales

^[35] Univ Melbourne, Florey Dept Neurosci & Mental Hlth, Melbourne, Vic - Australia

^[36] Austin Hlth, Dept Neurol, Heidelberg, Vic - Australia

^[37] Univ Southern Calif, Mark & Mary Stevens Inst Neuroimaging & Informat, Imaging Genet Ctr, Keck Sch Med, Marina Del Rey, CA - USA

^[38] Kuopio Univ Hosp, EpiCARE ERN, Kuopio - Finland

^[39] Univ Eastern Finland, Neurol, Inst Clin Med, Kuopio - Finland

^[40] Univ Liverpool, Inst Syst Mol & Integrat Biol, Liverpool, Merseyside - England

^[41] NHS Fdn Trust, Walton Ctr, Liverpool, Merseyside - England

^[42] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 - USA

^[43] Monash Univ, Cent Clin Sch, Dept Neurosci, Melbourne, Vic - Australia

^[44] Univ Florence, Childrens Hosp A Meyer, Neurosurg Dept, Funct & Epilepsy Neurosurg Unit, Florence - Italy

^[45] Univ Hosp Tubingen, Hertie Inst Clin Brain Res, Dept Neurol & Epileptol, Tubingen - Germany

^[46] Univ Florence, Mario Serio Dept Clin & Expt Med Sci, Florence - Italy

^[47] Cleveland Clin, Neurol Inst, Cleveland, OH 44106 - USA

^[48] NYU, Dept Neurol, Sch Med, New York, NY 10016 - USA

^[49] Univ Hosp Tubingen, Dept Diagnost & Intervent Neuroradiol, Tubingen - Germany

^[50] Univ Hosp Gottingen, Dept Clin Neurophysiol, Gottingen - Germany

^[51] McGill Univ, Montreal Neurol Inst & Hosp, Montreal, PQ - Canada

^[52] EEG & Epilepsy Unit, Geneva - Switzerland

^[53] Florey Inst Neurosci & Mental Hlth, Austin Campus, Heidelberg, Vic - Australia

^[54] Alfred Hlth, Melbourne, Vic - Australia

^[55] Monash Univ, Dept Neurosci, Melbourne, Vic - Australia

^[56] Henry Ford Hlth Syst, Radiol & Res Adm, Detroit, MI - USA

^[57] Univ Tehran, Coll Engn, Sch Elect & Comp Engn, Tehran - Iran

^[58] Univ Cape Town, Risk & Resilience Mental Disorders, Dept Psychiat, South African Med Res Council Unit Risk & Resilie, Cape Town - South Africa

^[59] Univ Cape Town, Risk & Resilience Mental Disorders, Neurosci Inst, Cape Town - South Africa

^[60] Ist Giannina Gaslini, IRCCS, Pediat Neurol & Musc Dis Unit, Genoa - Italy

^[61] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa - Italy

^[62] Newcastle Univ, Sch Comp, Newcastle Upon Tyne, Tyne & Wear - England

^[63] Newcastle Univ, Inst Translat & Clin Res, Newcastle Upon Tyne, Tyne & Wear - England

^[64] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Parkville, Vic - Australia

^[65] Royal Melbourne Hosp, Dept Neuropsychiat, Parkville, Vic - Australia

^[66] Royal Melbourne Hosp, Dept Neurol, Melbourne, Vic - Australia

^[67] Univ Bonn, Inst Expt Epileptol & Cognit Res, Bonn - Germany

^[68] Xiamen Univ, Sch Informat, Cognit Sci Dept, Xiamen - Peoples R China

^[69] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 - USA

• Document type: Review article
• Source: Human Brain Mapping; v. 43, n. 1, SI, p. 113-128, JAN 2022.
• Web of Science Citations: 11

Abstract

Epilepsy is a common and serious neurological disorder, with many different constituent conditions characterized by their electro clinical, imaging, and genetic features. MRI has been fundamental in advancing our understanding of brain processes in the epilepsies. Smaller-scale studies have identified many interesting imaging phenomena, with implications both for understanding pathophysiology and improving clinical care. Through the infrastructure and concepts now well-established by the ENIGMA Consortium, ENIGMA-Epilepsy was established to strengthen epilepsy neuroscience by greatly increasing sample sizes, leveraging ideas and methods established in other ENIGMA projects, and generating a body of collaborating scientists and clinicians to drive forward robust research. Here we review published, current, and future projects, that include structural MRI, diffusion tensor imaging (DTI), and resting state functional MRI (rsfMRI), and that employ advanced methods including structural covariance, and event-based modeling analysis. We explore age of onset- and duration-related features, as well as phenomena-specific work focusing on particular epilepsy syndromes or phenotypes, multimodal analyses focused on understanding the biology of disease progression, and deep learning approaches. We encourage groups who may be interested in participating to make contact to further grow and develop ENIGMA-Epilepsy. (AU)

• FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
• Grantee: Fernando Cendes
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC