nalysis of Cardiovascular Hemodynamic and Autonomic Variables in Individuals with Systemic Arterial Hypertension, Type 2 Diabetes Mellitus, and Parkinson's Disease: A Comparative Stud

Author(s)

Ngomane, Awassi Yuphiwa ^[1] ; de Abreu, Raphael Martins ^[2] ; Fernandes, Bianca ^[1] ; Marcal, Isabela Roque ^[1] ; Guimaraes, Guilherme Veiga ^[3] ; Ciolac, Emmanuel Gomes ^[1]

Affiliation

^[1] Sao Paulo State Univ, Sch Sci, Dept Phys Educ, Exercise & Chron Dis Res Lab, UNESP, Bauru, SP - Brazil

^[2] Fed Univ Sao Carlos UFSCar, Ctr Biol & Hlth Sci, Dept Phys Therapy, Cardiovasc Phys Therapy Lab, Sao Carlos - Brazil

^[3] Univ Sao Paulo, Sch Med, Heart Inst, Sao Paulo - Brazil

• Document type: Journal article
• Source: CLINICAL AND EXPERIMENTAL HYPERTENSION; v. 44, n. 2 DEC 2021.
• Web of Science Citations: 0

Abstract

Background Systemic arterial hypertension (SAH), type 2 diabetes mellitus (T2DM), and Parkinson's disease (PD) are highly prevalent chronic diseases that can significantly impact the cardiovascular system. Aim The aim of this study was to compare hemodynamic and autonomic variables at rest in individuals with SAH, T2DM, or PD. Methods Fifty sedentary or insufficiently active individuals (22 men) with SAH (age = 66 +/- 5.0 yr), T2DM (age = 52 +/- 10 yr) or PD (age = 68 +/- 8.0 yr) had their resting blood pressure (BP), arterial stiffness, endothelial function, and heart rate variability (HRV) assessed and compared. Results Systolic and diastolic BP were higher in SAH (130 +/- 10 / 80 +/- 10 mmHg) than T2DM (110 +/- 14 / 75 +/- 11 mmHg) and PD, and (123 +/- 20 / 70 +/- 11 mmHg) respectively. T2DM individuals showed lower arterial stiffness (8.4 +/- 1.1 m/s), when compared to SAH (10.3 +/- 2.3 m/s) and PD (10.6 +/- 3.0 m/s). T2DM had greater resting tachycardia showed by the mean RR (759 +/- 79 ms), than SAH (962 +/- 169 ms) and PD (976 +/- 134 ms), which was accompanied by higher sympathetic modulation (low frequency {[}LF]: 62 +/- 19 nu) and lower parasympathetic modulation (high frequency {[}HF]: 32 +/- 16 nu) when compared to SAH (LF: 40 +/- 16 nu; HF: 61 +/- 33 nu). No differences among groups were found on non-linear HRV markers and endothelial reactivity indexes. Conclusions Individuals with T2DM showed impaired levels of cardiac autonomic markers when compared to individuals with SAH and PD, despite of having lower levels of BP and arterial stiffness. (AU)

• FAPESP's process: 18/09695-5 - Hemodynamic response to heated water-based exercise in older individuals with hypertension: effect of high-intensity interval versus moderate-intensity continuous exercise
• Grantee: Isabela Roque Marcal
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 15/09259-2 - Acute hemodynamic responses to heated water-based exercise in older hypertensive patients
• Grantee: Awassi Yophiwa Ngomane
• Support Opportunities: Scholarships in Brazil - Master