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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ucoadhesive controlled-release formulations containing morin for the control of oral biofilm

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Author(s):
de Farias, Aline Leite [1] ; Arbelaez, Maria Isabel Amaya [2] ; Meneguin, Andreia Bagliotti [3] ; Barud, Hernane da Silva [4] ; Brighenti, Fernanda Lourencao [1]
Total Authors: 5
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Dent, Dept Morphol Pediat Dent & Orthodont, Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP - Brazil
[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, Araraquara, SP - Brazil
[4] Univ Araraquara UNIARA, Biopolymers & Biomat Lab BioPolMat, Araraquara, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: BIOFOULING; v. 38, n. 1 DEC 2021.
Web of Science Citations: 0
Abstract

This study aimed to evaluate the antimicrobial and anti-biofilm activity of morin on polymicrobial biofilms and its cytotoxicity in controlled-release films and tablets based on gellan gum. Polymicrobial biofilms were formed from saliva for 48 h under an intermittent exposure regime to 1% sucrose and in contact with films or tablets of gellan gum containing 2 mg of morin each. Acidogenicity, bacterial viability, dry weight and insoluble extracellular polysaccharides from biofilms were evaluated. The cytotoxicity of morin was evaluated in oral keratinocytes. Morin released from the systems reduced the viability of all the microbial groups evaluated, as well as the dry weight and insoluble polysaccharide concentration in the matrix and promoted the control of acidogenicity when compared with the control group without the substance. Morin was cytotoxic only at the highest concentration evaluated. In conclusion, morin is an effective agent and shows antimicrobial and anti-biofilm activity against polymicrobial biofilms. (AU)

FAPESP's process: 19/08375-0 - Maximization of the anti-caries and antibiofilm effect of conventional substances: evaluation in a polymicrobial biofilm model
Grantee:Fernanda Lourenção Brighenti
Support Opportunities: Regular Research Grants