What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from theENIGMABipolar Disorder Working Group

Author(s):Show less -

Ching, Christopher R. K. ^[1] ; Hibar, Derrek P. ^[2] ; Gurholt, Tiril P. ^{[3, 4]} ; Nunes, Abraham ^{[5, 6]} ; Thomopoulos, Sophia I. ^[1] ; Abe, Christoph ^{[7, 6]} ; Agartz, Ingrid ^{[8, 3, 9]} ; Brouwer, Rachel M. ^[10] ; Cannon, Dara M. ^[11] ; de Zwarte, Sonja M. C. ^[10] ; Eyler, Lisa T. ^{[12, 13]} ; Favre, Pauline ^{[14, 15]} ; Hajek, Tomas ^{[16, 4]} ; Haukvik, Unn K. ^{[4, 17]} ; Houenou, Josselin ^{[14, 15, 18]} ; Landen, Mikael ^{[19, 20]} ; Lett, Tristram A. ^{[21, 22]} ; McDonald, Colm ^[10] ; Nabulsi, Leila ^{[1, 10]} ; Patel, Yash ^[23] ; Pauling, Melissa E. ^{[14, 13]} ; Paus, Tomas ^{[24, 25, 23]} ; Radua, Joaquim ^{[8, 26, 27, 28]} ; Soeiro-de-Souza, Marcio G. ^[29] ; Tronchin, Giulia ^[10] ; van Haren, Neeltje E. M. ^[30] ; Vieta, Eduard ^{[26, 31]} ; Walter, Henrik ^[21] ; Zeng, Ling-Li ^{[1, 32]} ; Alda, Martin ^[4] ; Almeida, Jorge ^[33] ; Alnaes, Dag ^[3] ; Alonso-Lana, Silvia ^{[34, 3]} ; Altimus, Cara ^[35] ; Bauer, Michael ^[36] ; Baune, Bernhard T. ^{[37, 38, 39]} ; Bearden, Carrie E. ^{[40, 41]} ; Bellani, Marcella ^[42] ; Benedetti, Francesco ^{[43, 44]} ; Berk, Michael ^{[45, 46]} ; Bilderbeck, Amy C. ^{[39, 47, 48]} ; Blumberg, Hilary P. ^[49] ; Boen, Erlend ^{[43, 50]} ; Bollettini, Irene ^[44] ; del Mar Bonnin, Caterina ^{[26, 31]} ; Brambilla, Paolo ^{[51, 52]} ; Canales-Rodriguez, Erick J. ^{[34, 53, 54, 55]} ; Caseras, Xavier ^[56] ; Dandash, Orwa ^{[57, 58, 59]} ; Dannlowski, Udo ^[38] ; Delvecchio, Giuseppe ^[51] ; Diaz-Zuluaga, Ana M. ^[60] ; Dima, Danai ^{[61, 62]} ; Duchesnay, Edouard ^[14] ; Elvsashagen, Torbjorn ^{[63, 64, 17]} ; Fears, Scott C. ^{[65, 66]} ; Frangou, Sophia ^{[67, 68]} ; Fullerton, Janice M. ^{[69, 70]} ; Glahn, David C. ^{[71, 72]} ; Goikolea, Jose M. ^{[26, 31]} ; Green, Melissa J. ^{[73, 70]} ; Grotegerd, Dominik ^[38] ; Gruber, Oliver ^[74] ; Haarman, Bartholomeus C. M. ^[75] ; Henry, Chantal ^{[76, 77]} ; Howells, Fleur M. ^{[78, 79]} ; Ives-Deliperi, Victoria ^[79] ; Jansen, Andreas ^{[80, 81]} ; Kircher, Tilo T. J. ^[80] ; Knoechel, Christian ^[82] ; Kramer, Bernd ^[74] ; Lafer, Beny ^[83] ; Lopez-Jaramillo, Carlos ^{[60, 84]} ; Machado-Vieira, Rodrigo ^[85] ; MacIntosh, Bradley J. ^{[86, 87]} ; Melloni, Elisa M. T. ^{[43, 44]} ; Mitchell, Philip B. ^[73] ; Nenadic, Igor ^[80] ; Nery, Fabiano ^{[88, 89]} ; Nugent, Allison C. ^[90] ; Oertel, Viola ^[82] ; Ophoff, Roel A. ^{[91, 92]} ; Ota, Miho ^[93] ; Overs, Bronwyn J. ^[70] ; Pham, Daniel L. ^[35] ; Phillips, Mary L. ^[94] ; Pineda-Zapata, Julian A. ^[95] ; Poletti, Sara ^{[43, 44]} ; Polosan, Mircea ^{[96, 97]} ; Pomarol-Clotet, Edith ^{[34, 53]} ; Pouchon, Arnaud ^[96] ; Quide, Yann ^{[73, 70]} ; Rive, Maria M. ^[98] ; Roberts, Gloria ^[73] ; Ruhe, Henricus G. ^{[99, 100]} ; Salvador, Raymond ^{[34, 53]} ; Sarro, Salvador ^{[34, 53]} ; Satterthwaite, Theodore D. ^[101] ; Schene, Aart H. ^[99] ; Sim, Kang ^{[102, 103]} ; Soares, Jair C. ^{[104, 105]} ; Staeblein, Michael ^[82] ; Stein, Dan J. ^{[78, 79, 106]} ; Tamnes, Christian K. ^{[8, 3, 107]} ; Thomaidis, Georgios V. ^{[108, 109]} ; Upegui, Cristian Vargas ^[60] ; Veltman, Dick J. ^[110] ; Wessa, Michele ^[111] ; Westlye, Lars T. ^{[112, 113]} ; Whalley, Heather C. ^[114] ; Wolf, Daniel H. ^[101] ; Wu, Mon-Ju ^[105] ; Yatham, Lakshmi N. ^[115] ; Zarate, Carlos A. ^[116] ; Thompson, Paul M. ^[1] ; Andreassen, Ole A. ^{[3, 4]} ; Wor, ENIGMA Bipolar Disorder

Affiliation:Show less -

^[1] Univ Southern Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Keck Sch Med, Imaging Genet Ctr, Los Angeles, CA 90007 - USA

^[2] Genentech Inc, San Francisco, CA 94080 - USA

^[3] Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo - Norway

^[4] Oslo Univ Hosp, Div Mental Hlth & Addicit, Oslo - Norway

^[5] Dalhousie Univ, Dept Psychiat, Halifax, NS - Canada

^[6] Dalhousie Univ, Fac Comp Sci, Halifax, NS - Canada

^[7] Karolinska Inst, Dept Clin Neurosci, Stockholm - Sweden

^[8] Diakonhjemmet Hosp, Dept Psychiat Res, Oslo - Norway

^[9] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm - Sweden

^[10] Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr, Dept Psychiat, Utrecht - Netherlands

^[11] Natl Univ Ireland Galway, NCBES Galway Neurosci Ctr, Coll Med Nursing & Hlth Sci, Clin Neuroimaging Lab, Ctr Neuroimaging & Cognit Genom NICOG, Galway - Ireland

^[12] Univ Calif, Dept Psychiat, La Jolla, CA - USA

^[13] VA San Diego Healthcare, Desert Pacific MIRECC, San Diego, CA - USA

^[14] INSERM, U955, Team 15 Translat Neuropsychiat, Creteil - France

^[15] CEA Paris Saclay, Team UNIACT, Neurospin, Gif Sur Yvette - France

^[16] Natl Inst Mental Hlth, Klecany - Czech Republic

^[17] Oslo Univ Hosp, Norwegian Ctr Mental Disorders Res NORMENT, Oslo - Norway

^[18] Mondor Univ Hosp, AP HP, DMU IMPACT, Creteil - France

^[19] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm - Sweden

^[20] Univ Gothenburg, Dept Neurosci & Physiol, Gothenburg - Sweden

^[21] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin - Germany

^[22] Charite Univ Med Berlin, Dept Neurol Expt Neurol, Berlin - Germany

^[23] Holland Bloorview Kids Rehabil Hosp, Bloorview Res Inst, Toronto, ON - Canada

^[24] Univ Toronto, Dept Psychiat, Toronto, ON - Canada

^[25] Univ Toronto, Dept Psychol, Toronto, ON - Canada

^[26] Ctr Invest Biomed Red Salud Mental CIBERSAM, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona - Spain

^[27] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London - England

^[28] Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm - Sweden

^[29] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Mood Disorders Unit GRUDA, Sao Paulo, SP - Brazil

^[30] Erasmus MC, Dept Child & Adolescent Psychiat Psychol, Rotterdam - Netherlands

^[31] Univ Barcelona, Inst Neurosci, Barcelona Bipolar Disorders & Depress Unit, Hosp Clin, Barcelona - Spain

^[32] Natl Univ Def Technol, Coll Intelligence Sci & Technol, Changsha - Peoples R China

^[33] Univ Texas Austin, Dell Med Sch, Austin, TX 78712 - USA

^[34] CIBERSAM, Madrid - Spain

^[35] Milken Inst, Ctr Strateg Philanthropy, Washington, DC - USA

^[36] Tech Univ Dresden, Fac Med, Dept Psychiat & Psychotherapy, Dresden - Germany

^[37] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic - Australia

^[38] Univ Munster, Dept Psychiat, Munster - Germany

^[39] Univ Melbourne, Dept Psychiat, Melbourne, Vic - Australia

^[40] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA - USA

^[41] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 - USA

^[42] Univ Verona, Dept Neurosci Biomed & Movement Sci, Sect Psychiat, Verona - Italy

^[43] Univ Vita Salute San Raffaele, Milan - Italy

^[44] IRCCS San Raffaele Sci Inst, Psychiat & Psychobiol, Div Neurosci, Milan - Italy

^[45] Univ Milan, Dept Pathophysiol & Transplantat, Milan - Italy

^[46] Deakin Univ, IMPACT Inst, Inst Mental & Phys Hlth & Clin Translat, Sch Med, Barwon Hlth, Geelong, Vic - Australia

^[47] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Natl Ctr Excellence Youth Mental Hlth, Ctr Youth Mental Hlth, Melbourne, Vic - Australia

^[48] P1vital Ltd, Wallingford, Oxon - England

^[49] Univ Oxford, Dept Psychiat, Oxford - England

^[50] Yale Sch Med, Mood Disorders Res Program, New Haven, CT - USA

^[51] Oslo Univ Hosp, Psychosomat & CL Psychiat, Oslo - Norway

^[52] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Dept Neurosci & Mental Hlth, Milan - Italy

^[53] FIDMAG Germanes Hosp Res Fdn, Barcelona - Spain

^[54] Ctr Hosp Univ Vaudois CHUV, Dept Radiol, Lausanne - Switzerland

^[55] Ecole Polytech Fed Lausanne, Signal Proc Lab LTS5, Lausanne - Switzerland

^[56] Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Cardiff - Wales

^[57] Melbourne Hlth, Melbourne, Vic - Australia

^[58] Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne, Vic - Australia

^[59] Monash Univ, Brain Mind & Soc Res Hub, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic - Australia

^[60] Univ Antioquia, Fac Med, Dept Psychiat, Res Grp Psychiat GIPSI, Medellin - Colombia

^[61] Univ London, Sch Social Sci & Arts, Dept Psychol, London - England

^[62] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neuroimaging, London - England

^[63] Univ Oslo, Inst Clin Med, Oslo - Norway

^[64] Oslo Univ Hosp, Dept Neurol, Oslo - Norway

^[65] Ctr Neurobehav Genet, Los Angeles, CA - USA

^[66] Greater Los Angeles Vet Adm, Los Angeles, CA - USA

^[67] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 - USA

^[68] Univ British Columbia, Ctr Brain Hlth, Vancouver, BC - Canada

^[69] Univ New South Wales, Sch Med Sci, Sydney, NSW - Australia

^[70] Neurosci Res Australia, Randwick, NSW - Australia

^[71] Harvard Med Sch, Boston, MA 02115 - USA

^[72] Boston Childrens Hosp, Dept Psychiat, Boston, MA - USA

^[73] Univ New South Wales, Sch Psychiat, Sydney, NSW - Australia

^[74] Heidelberg Univ, Dept Gen Psychiat, Heidelberg - Germany

^[75] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen - Netherlands

^[76] Serv Hosp Univ, GHU Paris Psychiat & Neurosci, Dept Psychiat, Paris - France

^[77] Univ Paris, Paris - France

^[78] Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town - South Africa

^[79] Univ Cape Town, Inst Neurosci, Cape Town - South Africa

^[80] Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg - Germany

^[81] Univ Marburg, Fac Med, Core Facil Brainimaging, Marburg - Germany

^[82] Goethe Univ Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt - Germany

^[83] Univ Sao Paulo, Hosp Clin HCFMUSP, Lab Psychiat Neuroimaging LIM 21, Dept & Inst Psiquiatria, Fac Med, Sao Paulo, SP - Brazil

^[84] Hosp Univ Trastorno Animo, Mood Disorders Program, Medellin - Colombia

^[85] Univ Texas Houston, Dept Psychiat, Expt Therapeut & Mol Pathophysiol Program, UTHlth, Houston, TX - USA

^[86] Univ Toronto, Dept Med Biophys, Toronto, ON - Canada

^[87] Sunnybrook Res Inst, Hurvitz Brain Sci, Toronto, ON - Canada

^[88] Univ Sao Paulo, Sao Paulo, SP - Brazil

^[89] Univ Cincinnati, Cincinnati, OH - USA

^[90] MEG Core Facil, Bethesda, MD - USA

^[91] Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA - USA

^[92] Erasmus Univ, Erasmus Med Ctr, Dept Psychiat, Rotterdam - Netherlands

^[93] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, Tokyo - Japan

^[94] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA - USA

^[95] Inst Alta Tecnol Med IATM, Res Grp, Medellin - Colombia

^[96] Univ Grenoble Alpes, CHU Grenoble Alpes, Grenoble - France

^[97] INSERM, U1216, Grenoble Inst Neurosci, La Tronche - France

^[98] Locat AMC, Amsterdam UMC, Dept Psychiat, Amsterdam - Netherlands

^[99] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Nijmegen - Netherlands

^[100] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen - Netherlands

^[101] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 - USA

^[102] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore - Singapore

^[103] Inst Mental Hlth, West Reg, Singapore - Singapore

^[104] UTHlth Houston, Ctr Excellent Mood Disorders, Houston, TX - USA

^[105] UTHlth Houston, Dept Psychiat & Behav Sci, Houston, TX - USA

^[106] Univ Cape Town, SAMRC Unit Risk & Resilience Mental Disorders, Cape Town - South Africa

^[107] Univ Oslo, Dept Psychol, PROMENTA Res Ctr, Oslo - Norway

^[108] Papanikolaou Gen Hosp, Thessaloniki - Greece

^[109] Aristotle Univ Thessaloniki, Sch Engn, Lab Mech & Mat, Thessaloniki - Greece

^[110] Amsterdam UMC, Dept Psychiat, Amsterdam - Netherlands

^[111] Johannes Gutenberg Univ Mainz, Dept Neuropsychol & Clin Psychol, Mainz - Germany

^[112] Univ Oslo, Dept Psychol, Oslo - Norway

^[113] Oslo Univ Hosp, Dept Mental Hlth & Addict, Norwegian Ctr Mental Disorders Res NORMENT, Oslo - Norway

^[114] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian - Scotland

^[115] Univ British Columbia, Dept Psychiat, Vancouver, BC - Canada

^[116] NIMH, Intramural Res Program, Bethesda, MD 20892 - USA

• Document type: Review article
• Source: Human Brain Mapping; v. 43, n. 1, SI, p. 56-82, JAN 2022.
• Web of Science Citations: 12

Abstract

MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness. (AU)

• FAPESP's process: 10/18672-7 - SPECGENE: genetic association study between single nucleotide polymorphisms of GAD1 and reelin and magnetic ressonance spectroscopy in bipolar I
• Grantee: Ricardo Alberto Moreno
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/03905-4 - NEUROBIOLOGICAL DIFFERENCES BETWEEN TREATMENT-NAIVE PATIENTS WITH BIPOLAR DISORDER SUBTYPES I AND II
• Grantee: Marcus Vinicius Zanetti
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 09/14891-9 - Longitudinal study on the neuroprotective and neurotrophic effects of lithium in bipolar disorder: identification of cellular and molecular targets clinically relevant
• Grantee: Rodrigo Machado-Vieira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 12/23796-2 - "Genetic association study between cognitive performance, polymorphisms of GAD1/Reelin and 3T magnetic ressonance spectroscopy of GABA/glutamate in bipolar I disorder and healthy controls"
• Grantee: Márcio Gerhardt Soeiro-de-Souza
• Support Opportunities: Scholarships in Brazil - Post-Doctoral