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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

easibility of intravoxel incoherent motion in the assessment of tumor microvasculature and blood-brain barrier integrity: a case-based evaluation of glioma

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Author(s):
Paschoal, Andre Monteiro [1, 2, 3] ; Zotin, Maria Clara Zanon [2, 4] ; da Costa, Lucas Murilo [3] ; dos Santos, Antonio Carlos [2] ; Leoni, Renata Ferranti [3]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst & Dept Radiol, LIM44, Fac Med, BR-05403010 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Med Sch Ribeirao Preto, BR-14040900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, InBrain Lab, FFCLRP, BR-14040900 Ribeirao Preto, SP - Brazil
[4] Harvard Med Sch, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 - USA
Total Affiliations: 4
Document type: Journal article
Source: MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE; v. 35, n. 1, SI DEC 2021.
Web of Science Citations: 0
Abstract

Objective To evaluate the feasibility of intravoxel incoherent motion (IVIM) in assessing blood-brain barrier (BBB) integrity and microvasculature in tumoral tissue of glioma patients. Methods Images from 8 high-grade and 4 low-grade glioma patients were acquired on a 3 T MRI scanner. Acquisition protocol included pre- and post-contrast T1- and T2-weighted imaging, FLAIR, dynamic susceptibility contrast (DSC), and susceptibility-weighted imaging (SWI). In addition, IVIM was acquired with 15 b-values and fitted under the non-negative least square (NNLS) model to output the diffusion (D) and pseudo-diffusion (D{*}) coefficients, perfusion fraction (f), and f times D{*} (fD{*}) maps. Results IVIM perfusion-related maps were sensitive to (1) blood flow and perfusion alterations within the microvasculature of brain tumors, in agreement with intra-tumoral susceptibility signal (ITSS); (2) enhancing areas of BBB breakdown in agreement with DSC maps as well as areas of BBB abnormality that was not detected on DSC maps; (3) enhancing perfusion changes within edemas; (4) detecting early foci of increased perfusion within low-grade gliomas. Conclusion The results suggest IVIM may be a promising approach to delineate tumor extension and progression in size, and to predict histological grade, which are clinically relevant information that characterize tumors and guide therapeutic decisions in patients with glioma. (AU)

FAPESP's process: 19/06148-6 - Methodological development for the noninvasive assessment of the blood-brain barrier permeability in diffuse gliomas
Grantee:Renata Ferranti Leoni
Support Opportunities: Regular Research Grants