Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients

Author(s):Show less -

Buosi, Patrick ^{[1, 2]} ; Borghi, Fabio Aparecido ^{[1, 2]} ; Lopes, Angelica Marta ^[1] ; Facincani, Isabela da Silva ^[1] ; Fernandes-Ferreira, Rafael ^{[3, 4]} ; Oliveira-Brancati, Camila Ive Ferreira ^[1] ; do Carmo, Tayanne Silva ^[1] ; Silva, Doroteia Rossi ^[1] ; da Silva, Danilo Grunig Humberto ^[5] ; de Almeida, Eduardo Alves ^[6] ; de Araujo Filho, Gerardo Maria ^{[1, 2]}

Affiliation

^[1] FAMERP, Sao Jose Do Rio Preto, SP - Brazil

^[2] Fac Med Sao Jose do Rio Preto FAMERP, Hosp Base, Sao Jose Do Rio Preto, SP - Brazil

^[3] Univ Estadual Campinas UNICAMP, Campinas, SP - Brazil

^[4] Univ Paulista UNIP, Sao Jose Do Rio Preto, SP - Brazil

^[5] Univ Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas Campus, Sao Jose Do Rio Preto Campus UNESP, Sao Jose Do Rio Preto, SP - Brazil

^[6] Univ Reg Blumenau FURB, Dept Ciencias Nat, Blumenau, SC - Brazil

• Document type: Journal article
• Source: Trends in Psychiatry and Psychotherapy; v. 43, n. 4, p. 278-285, OCT-DEC 2021.
• Web of Science Citations: 0

Abstract

Abstract Introduction Schizophrenia is a complex psychiatric disorder that affects approximately twenty million people worldwide. Various factors have been associated with the physiopathology of this disease such as oxidative stress, which is an imbalance between pro-oxidant and antioxidant molecules. Objective This study evaluated the association between biomarkers of oxidative stress and response to pharmacological treatment among patients with schizophrenia in the context of their clinical information, demographic data, and lifestyle. Methods A total of 89 subjects were included, 26 of whom were treatment-responsive schizophrenia patients (Group 1), 27 treatment-resistant schizophrenia patients (Group 2), and 36 healthy controls (Group 3). All of the subjects completed a questionnaire to provide clinical and demographic data, and all provided peripheral blood samples. The oxidative stress markers analyzed using spectrophotometry were catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), total glutathione (GSH-t), malondialdehyde (MDA), and Trolox-equivalent antioxidant capacity (TEAC; p < 0.05). Results When all schizophrenia patients (G1 + G2) were compared to the control group, SOD levels were found to be lower among schizophrenia patients (p < 0.0001), while MDA and CAT levels were higher (p < 0.0001 and p = 0.0191, respectively). GPx, GSH-t, and TEAC levels were similar in all three groups (p > 0.05). Conclusion Lower SOD levels and higher MDA and CAT levels indicate oxidative damage in schizophrenia patients, regardless of their response to pharmacological treatment. Smoking is associated with oxidative stress, in addition, a family history of the disease was also found to be correlated with cases of schizophrenia, which reflects the relevance of genetics in disease development. (AU)

• FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
• Grantee: Ohara Augusto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC