Mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains

Author(s):Show less -

Borrego, Andrea ^[1] ; Jensen, Jose Ricardo ^[1] ; Koury Cabrera, Wafa Hanna ^[1] ; Massa, Solange ^[1] ; Ribeiro, Orlando Garcia ^[1] ; Starobinas, Nancy ^[1] ; De Franco, Marcelo ^[2] ; Eto, Silas Fernandes ^[3] ; Manenti, Giacomo ^[4] ; Dragani, Tommaso Antonio ^[4] ; Ibanez, Olga Martinez ^[1]

Affiliation

^[1] Inst Butantan, Lab Immunogenet, Sao Paulo - Brazil

^[2] Inst Pasteur, Diagnost Sect, Sao Paulo - Brazil

^[3] Inst Butantan, Lab Dev & Innovat, Sao Paulo - Brazil

^[4] Ist Nazl Tumori Milano, Fdn IRCCS, Genet Epidemiol & Pharmacogen Unit, Milan - Italy

• Document type: Journal article
• Source: Genes and Immunity; DEC 2021.
• Web of Science Citations: 0

Abstract

Two non-inbred mouse lines, phenotypically selected for maximal (AIRmin) and minimal (AIRmax) acute inflammatory response, show differential susceptibility/resistance to the development of several chemically-induced tumor types. An intercross pedigree of these mice was generated and treated with the chemical carcinogen dimethylhydrazine, which induces lung and intestinal tumors. Genome wide high-density genotyping with the Restriction Site-Associated DNA genotyping (2B-RAD) technique was used to map genetic loci modulating individual genetic susceptibility to both lung and intestinal cancer. Our results evidence new common quantitative trait loci (QTL) for those phenotypes and provide an improved understanding of the relationship between genomic variation and individual genetic predisposition to tumorigenesis in different organs. (AU)

• FAPESP's process: 17/50407-0 - High density genome wide genotyping on a pedigree of AIRmin and AIRmax mice to map and characterize new loci involved in lung and intestinal tumour development
• Grantee: Olga Celia Martinez Ibanez
• Support Opportunities: Regular Research Grants