Increased levels of TAR DNA-binding protein 43 in the hippocampus of subjects with bipolar disorder: a postmortem study

Author(s):Show less -

Nascimento, Camila ^[1] ; Nunes, V, Paula ; Kim, Helena K. ^[2] ; Leite, Renata E. P. ^[3] ; Rodriguez, Roberta D. ^[3] ; De Oliveira, Katia Cristina ^[4] ; Brentani, Helena P. ^[5] ; Jacob-Filho, Wilson ^[3] ; Nitrini, Ricardo ^[3] ; Pasqualucci, Carlos A. ^[3] ; Grinberg, Lea T. ^{[6, 3]} ; Suemoto, Claudia K. ^[3] ; Lafer, Beny ^[5]

Affiliation

^[1] Univ Sao Paulo, Dept Psychiat, Med Sch, Sao Paulo, SP - Brazil

^[2] Univ Toronto, Dept Psychiat, Toronto, ON - Canada

^[3] Univ Sao Paulo, Brazilian Biobank Aging Studies, Med Sch, Sao Paulo, SP - Brazil

^[4] Fed Univ ABC, Sao Bernardo Do Campo, SP - Brazil

^[5] Nunes, Paula, V, Univ Sao Paulo, Dept Psychiat, Med Sch, Sao Paulo, SP - Brazil

^[6] Univ Calif San Francisco, Memory & Aging Ctr, San Francisco, CA 94143 - USA

• Document type: Journal article
• Source: JOURNAL OF NEURAL TRANSMISSION; v. 129, n. 1, p. 95-103, JAN 2022.
• Web of Science Citations: 0

Abstract

Bipolar disorder shares symptoms and pathological pathways with other neurodegenerative diseases, including frontotemporal dementia (FTD). Since TAR DNA-binding protein 43 (TDP-43) is a neuropathological marker of frontotemporal dementia and it is involved in synaptic transmission, we explored the role of TDP-43 as a molecular feature of bipolar disorder (BD). Homogenates were acquired from frozen hippocampus of postmortem brains of bipolar disorder subjects. TDP-43 levels were quantified using an ELISA-sandwich method and compared between the postmortem brains of bipolar disorder subjects and age-matched control group. We found higher levels of TDP-43 protein in the hippocampus of BD (n = 15) subjects, when compared to controls (n = 15). We did not find associations of TDP-43 with age at death, postmortem interval, or age of disease onset. Our results suggest that protein TDP-43 may be potentially implicated in behavioral abnormalities seen in BD. Further investigation is needed to validate these findings and to examine the role of this protein during the disease course and mood states. (AU)

• FAPESP's process: 17/07089-8 - Investigating TDP-43 as neuromarker of Bipolar Disorder
• Grantee: Camila Nascimento Mantelli
• Support Opportunities: Scholarships in Brazil - Post-Doctoral