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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In Vivo and In Vitro Taste Assessment of Artesunate-Mefloquine, Praziquantel, and Benznidazole Drugs for Neglected Tropical Diseases and Pediatric Patients

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Boniatti, Janine [1, 2] ; Tappin, Marcelo R. R. [1] ; Teixeira, Rafaela G. da S. [3] ; Gandos, V, Tamires de A. ; Rios, Luis P. S. [4] ; Ferreira, Izabelle A. M. [4] ; Oliveira, Karina C. [4] ; Calil-Elias, Sabrina [4] ; Santana, Aila K. M. [5] ; da Fonseca, Lais B. [6] ; Shimizu, Flavio M. [7] ; Carr, Olivia [8] ; Oliveira Jr, Osvaldo N. ; Dantas, Fabio M. L. [2] ; Amendoeira, Fabio C. [6] ; Vicosa, Alessandra L. [6]
Total Authors: 16
Affiliation:
[1] Fundacao Oswaldo Cruz, Sizenando Nabuco St 100, Rio De Janeiro, RJ - Brazil
[2] Natl Inst Technol, Mat Dept, Rio De Janeiro, RJ - Brazil
[3] Fed Fluminense Univ, Fac Pharm, Niteroi, RJ - Brazil
[4] Gandos, Tamires de A., V, Fed Fluminense Univ, Fac Pharm, Niteroi, RJ - Brazil
[5] Pharmaceut Lab State Pernambuco Lafepe, Recife, PE - Brazil
[6] Gandos, Tamires de A., V, Fundacao Oswaldo Cruz, Sizenando Nabuco St 100, Rio De Janeiro, RJ - Brazil
[7] Univ Campinas UNICAMP, Gleb Wataghin Inst Phys IFGW, Dept Appl Phys, BR-13083859 Campinas, SP - Brazil
[8] Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 8
Document type: Journal article
Source: AAPS PHARMSCITECH; v. 23, n. 1 DEC 14 2021.
Web of Science Citations: 0
Abstract

The assessment of drug taste is crucial for pediatric treatments so that formulations can be developed to enhance their effectiveness. In this study, in vivo and in vitro methods were applied to evaluate the taste of tablets of three drugs administered to children without taste-masking excipients to treat tropical diseases, namely artesunate-mefloquine (ASMQ), praziquantel (PZQ), and benznidazole (BNZ). In the first method, a model of rat palatability was adapted with recirculation to ensure sample dispersion, and the data were analyzed using ANOVA (single factor, 95%). The taste assessment results (in vivo) indicated an aversion to the three medicines, denoted by the animals retracting themselves to the bottom of the box after the first contact with the drugs. For the placebo samples, the animals behaved normally, indicating that taste perception was acceptable. The second method was based on the in vitro analysis of capacitance data from a homemade impedimetric electronic tongue. Consistent with the in vivo taste assessment results, the data points obtained with PZQ, ASMQ, and BNZ were far away from those of their placebos in a map built with the multidimensional projection technique referred to as Interactive Document Mapping (IDMAP). A combined analysis of the results with the two methods allowed us to confirm the bitterness of the three drugs, also pointing to electronic tongues as a promising tool to replace in vivo palatability tests. (AU)

FAPESP's process: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis
Grantee:Osvaldo Novais de Oliveira Junior
Support Opportunities: Research Projects - Thematic Grants