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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mechanochemical synthesis, thermoanalytical study and characterization of new multicomponent solid forms of norfloxacin with saccharin

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Author(s):
Ferreira, Patricia Osorio [1, 2] ; de Moura, Aniele [2] ; de Almeida, Amanda Cosmo [2] ; dos Santos, Everton Carvalho [2] ; Kogawa, Ana Carolina [3] ; Caires, Flavio Junior [1, 2]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Chem, Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Dept Chem, Sch Sci, Bauru, SP - Brazil
[3] Fed Univ Goias UFG, Sch Pharm, Goiania, Go - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. 147, n. 3, p. 1985-1997, FEB 2022.
Web of Science Citations: 1
Abstract

Cocrystallization is a very efficient strategy to improve the physicochemical properties of bioactive agents. A new norfloxacin (NOR)-saccharin cocrystal and a cocrystal-solvate were synthesized through the mechanochemical method (neat and liquid-assisted grinding), and the characterization was performed by thermal analysis (TG-DTA, DSC and DSC microscopy), infrared vibrational spectroscopy and powder X-ray diffraction. Moreover, solubility experiments carried out in water and buffer solutions (pH 3.0, 6.1 and 8.5) showed that norfloxacin has an aqueous solubility 3.5 times higher when cocrystallized with saccharin than in its pristine state, and an inverted pH-dependency compared to NOR alone (2 times higher in 6.1, slightly increase in pH 3.0, and a decrease of 0.7 times in 8.5 buffer solution). Furthermore, the solvate-cocrystal has a water solubility 2.3 times higher than NOR and the same solubility in 6.1 buffer solution than the cocrystal (2 times higher than NOR alone). (AU)

FAPESP's process: 18/24378-6 - Synthesis, characterization and thermoanalytical study of Valsartan, Candesartan Cilexetil and Olmesartan medoxomil co-crystals
Grantee:Flávio Junior Caires
Support Opportunities: Regular Research Grants
FAPESP's process: 17/14936-9 - Preparation, characterization and thermoanalytical studies of heterogeneous catalysts of double selenates of Mg/Co and Mg/Cu in biodiesel production using different oils
Grantee:Massao Ionashiro
Support Opportunities: Regular Research Grants
FAPESP's process: 13/09022-7 - Thermoanalytical studies, synthesis and characterization of the solid co-crystals of antibiotics (fluoroquinolones) with some co-formers
Grantee:Massao Ionashiro
Support Opportunities: Regular Research Grants